Reactive Oxygen Species Turns Men Infertile but Vitamin C Prohibits - Behind the Scene

Review Article

Austin Andrology. 2016; 1(2): 1009.

Reactive Oxygen Species Turns Men Infertile but Vitamin C Prohibits - Behind the Scene

Sahu CR*

Department of Zoology, University of Kalyani, India

*Corresponding author: Sahu CR, Department of Zoology, University of Kalyani, Kalyani-741235, India

Received: September 30, 2016; Accepted: October 19, 2016; Published: October 21, 2016


Now-a-days, a fair number of the married couples are worried about the menace of infertility where the male partner is almost a concerned part of the “problem. Modern advances in this field of study have directed mankind to” search for the causes of the problem leading to infertility. The present review is focused on the causes and factors of sperm dysfunction related to the problem. The quality and quantity of the sperm is one of the causes of sperm infertility. Besides, ROS also plays an important role in infertility resulting in the failure of the sperm to fertilize. The use of antioxidants especially vitamin C helps to curb this sort of complications. The present review has been penned down through some basic steps that lead to infertility, which need to be understood to facilitate a solution towards the menace of infertility.

Keywords: Reactive Oxygen Species; Infertility; Vitamin C


ROS: Reactive Oxygen Species; SOD: Superoxide Dismutase; GPX: Glutathione Peroxidase; NADPH oxidase: Nicotinamide Adenine Dinucleotide Phosphate-oxidase


Infertility is a big word linked with the inability to procreate a new individual, as offspring, being produced by their parents, involving two distinct types of specialized reproductive cells as gametes, coming both from female as well as male. The menace of infertility, in question, is not involved with the females only; rather males also play a pivotal role in true sense of term. The global prevalence rates in infertility are very difficult to determine due to their occurrences in both males and females but they affect one in four couples of developing countries [1]. In the global scenarios (Figure 1), where 15% of the couples are infertile, [2] out of which 50% of the cases are the end results of the male infertility. The main problems underlining the male infertility are either restricted sperm production or blockage of sperm transport. If the production is less or the quality of the sperm is poor, the fertility cannot be achieved. Besides these, obstructions in the tubes that help to pass sperm from the testis to the penis also account for a condition of lack of sperm causing infertility. Less common causes of infertility also include sexual problems, low hormonal levels and sperm antibodies [3]. Besides, the sperms, as main reproductive cells, get damaged due to the production of too much of free radicals or reactive oxygen species (ROS) and those are the main subjects of discussion in the present review. Further, the rationale of this review is to explore the impacts of ROS on the function of the sperm, reasons for generation of ROS and the possibility of the use of vitamin C as an antioxidant that recovers the damage to sperm.

Citation:Sahu CR. Reactive Oxygen Species Turns Men Infertile but Vitamin C Prohibits - Behind the Scene. Austin Andrology. 2016; 1(2): 1009.