Clinical Risk Estimation of Advanced Age-Related Macular Degeneration in Women with Breast Arterial Calcifications

Research Article

Austin J Clin Ophthalmol. 2016; 3(3): 1073.

Clinical Risk Estimation of Advanced Age-Related Macular Degeneration in Women with Breast Arterial Calcifications

Saa J1,2*, Fernández-Guinea O2,3, García-Pravia P³, Eiró N², Del Casar JM2,4, Galindo J¹, Baamonde B5 and Vizoso FJ2,4

¹Department of Ophthalmology, Fundación Hospital de Jove, Spain

²Research Unit, Fundación Hospital de Jove, Spain

³Department of Radiodiagnosis, Fundación Hospital de Jove, Spain

4Department of Surgery, Fundación Hospital de Jove, Spain

5Department of Ophthalmology, University of Oviedo, Spain

*Corresponding author: Saa J, Department of Ophthalmology, Jove Hospital Foundation, Eduardo Castro s/n, 33290 Gijón, Spain

Received: August 24, 2016; Accepted: November 23, 2016; Published: November 28, 2016

Abstract

Objective/Method: The purpose of the study is to calculate the probability of risk of advanced Age-Related Macular Degeneration (AMD) using a validated risk calculator in women with breast arterial calcifications (BAC) from a screening breast cancer program.

Results/Conclusion: Average probability of advanced AMD in women with BAC were higher than controls. Thus, this could be a preliminary follow-up study to raise the detection of a possible risk group of AMD from a screening is performed and systematic in the normal practice.

Keywords: Age-related macular degeneration; Breast arterial calcifications; Mammograms; Risk calculator

Abbreviations

AMD: Age-related Macular Degeneration; BAC: Breast Arterial Calcifications

Introduction

Age-related Macular Degeneration (AMD) is a common cause of vision loss in people over 65 years with a complex pathophysiology that includes risk factors such as age, genetic and cardiovascular factors [1]. On the other hand, in our midst a population screening in women aged 50 to 70 years for the detection of breast cancer including mammography is performed biennially [2]. The appearance of Breast Arterial Calcifications (BAC) on mammograms occurs in 8% of cases and have been associated with cardiovascular morbidity and mortality [3,4].

In a study conducted by our group on a hospital population has been associated, after multivariate analysis independently the presence of suggestive eye fund us changes of AMD with the presence of BAC, hypertension and overweight women between 50 and 70 years [5]. In the present study the data obtained in previous work assessing the likelihood of developing advanced AMD in women with BAC using a validated clinical risk calculator.

Subjects and Methods

They have been included in this study woman between 50 and 70 years of a population screening program for breast cancer at the Hospital Foundation Jove Gijon (Spain). 71 women with BAC and 50 women without BAC were included in the study. BAC mammographic diagnosis was made according to the recommendations of the American College of Radiology (Figure 1). The study was followed according to the Declaration of Helsinki.