An Overview on Emerging Trends in Immediate Release Tablet Technologies

Review Article

Austin Therapeutics. 2016; 3(1): 1026.

An Overview on Emerging Trends in Immediate Release Tablet Technologies

Pande V, Karale P, Goje P and Mahanavar S*

Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, India

*Corresponding author: Sachin Mahanavar, Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, India

Received: April 18, 2016; Accepted: June 23, 2016; Published: June 28, 2016

Abstract

Tablet is the most popular among all dosage forms existing today because of its convenience of self-administration, compactness and easy manufacturing; however in many cases immediate onset of action is required than conventional therapy. To overcome these drawbacks, immediate release pharmaceutical dosage form has emerged as alternative oral dosage forms. The basic approach used in development tablets is the use of superdisintegrant, Tablet molding technique, Direct compression technique, Granulation technique, Mass extrusion technique which provide instantaneous disintegration of tablet after administration. The recent development in immediate release tablets such as Novel granulation technologies, electrostatic dry powder coating process, Novel Hole Technology in Fast Dissolving Tablets, Hot-Melt Extrusion and Injection Molding also provides an opportunity for a line extension in the market place. Now a day, immediate release formulations are similar to many sustained release formulations that are now commonly available.

Keywords: Immediate release; Granulation; Excipients; Drug Delivery

Introduction

Oral route of administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance. Also solid oral delivery systems does not need sterile conditions and are therefore, less expensive to manufacture. Patient compliance, high precision dosing, and manufacturing efficiency make tablets the solid dosage form of choice. There is requirement for new oral drug delivery system because of poor patient acceptance for invasive methods, requirement for investigation of new market for drugs and combined with high cost of disease management. Developing new drug delivery techniques and that utilizing in product development is critical for pharma companies to survive this century [1,2].

The term ‘immediate release’ pharmaceutical formulation is the formulation in which the rate of release of drug and/or the absorption of drug from the formulation, is neither appreciably, nor intentionally, retarded by galenic manipulations. Immediate release dosage form is those which break down quickly and get dissolved to release the medicaments. In the present case, immediate release may be provided of an appropriate pharmaceutically acceptable diluent or carrier, which diluent or carrier does not delay, to an appreciable extent, the rate of drug release and/or absorption [3-5].

Immediate release drug delivery is suitable for drugs having long biological half-life, high bioavailability, lower clearance and lower elimination half-life. But main requirement for immediate release dosage form is poor solubility of the drug and need the immediate action of drug to treat undesirable imperfection or disease [6] (Table 1,2).

Citation: Pande V, Karale P, Goje P and Mahanavar S. An Overview on Emerging Trends in Immediate Release Tablet Technologies. Austin Therapeutics. 2016; 3(1): 1026. ISSN:2472-3673