Novel Sensors for Potentiometric Determination of Diphenhydramine Hydrochloride

Research Article

Austin J Anal Pharm Chem. 2019; 6(3): 1121.

Novel Sensors for Potentiometric Determination of Diphenhydramine Hydrochloride

Rana A. Hammza, Ekhlas A. Salman Al Zubiady, Amina M. Abass*

Chemistry Department, College of Sciences, Al-Nahrain University, Al-Jaderia, Baghdad, Iraq

*Corresponding author: Amina M. Abass, Chemistry Department, College of Sciences, Al-Nahrain University, Al-Jaderia, Baghdad, Iraq

Received: August 20, 2019; Accepted: September 18, 2019; Published: September 25, 2019

Abstract

The formation and working properties of sensor membranes for a just now found Diphenhydramine (DPH) deal with its ion-pair complexes with Phosphotungestic Acid (PTA) in a poly (vinyl chloride) (PVC) matrix were explained. More suitable sensor for determination of diphenhydramine was based on di-n-butyl phthalate (DBPH) as the plasticizer. This sensor exhibits a Nernstian response (52.50mV decade-1) with range 4.7x10-6 to 1.0x10-1 M of DPH solutions with PH working about (3.0-5.5). Selectivity of this sensor to DPH in the existence of cations is reported. The second electrode which prepared from di-n-butyl phosphate (DBP) as a plasticizer was gave a small value of slope near to (8.5mV per decade) with concentration range equal to 4.8x10-6- 1.0x10-3 M, PH range was (1.5-3.5). Also selectivity coefficient was calculated for electrode depended on DBPH as a plasticizer in opposition to some cations. The potentiometric methods are used to determine the DPH quantity in pure and pharmaceutical production.

Keywords: Diphenhydramine; Sensors; Liquid Membrane; Plasticizers; PVC; Selectivity

Introduction

Sensors have long suit vital and trustworthy devices for chemical, biomedical and pharmaceutical laboratory research; they are have a varied range of usage, well to use, also low-cost. More of prevailing values for the formation of membrane, s sensor is the adding up of a lipophilic ion-pair complex into a to a great extent plasticized membrane. Suitable sensor or liquid membrane electrode for drugs have sufficient selectivity to the drugs over pharmaceutical excipients and they can be beneficial in the quantifiable analysis of the drugs in pharmaceutical formulations with no earlier separations. In specific, sensors are actual beneficial in the item in point of drugs which are unsteady through prior separation. Diphenhydramine(2- (diphenyImethoxy)-N, N- dimethyethylamine hydrochloride, see in Figure 1, is a H1-receptor antagonist used clinically for its antihistaminic, antiemetic, sedative and local anaesthetic influences. It has also been used for the prevention and treatment of vomiting, nausea, and for the control of Parkinsonian symptoms [1,2].