Potential Role of Mirnas in Rheumatoid Arthritis

Short Communication

Austin Arthritis.2016; 1(2): 1009.

Potential Role of Mirnas in Rheumatoid Arthritiss

Jithin S Sunny¹, Snijesh VP² and Sachidanand Singh²*

¹Department of Bioinformatics, SRM University, Kancheepuram, Tamil Nadu, India

²Department of Biosciences and Technology, Karunya University, Coimbatore, Tamil Nadu, India

*Corresponding author: Sachidanand Singh, Department of Biosciences and Technology, Karunya University, Coimbatore, Tamil Nadu, India

Received: July 20, 2016; Accepted: July 27, 2016; Published: July 29, 2016

Short Communication

Rheumatoid Arthritis (RA) is a chronic multifactorial disease which is affecting 1% of the world population. It is a persistent, debilitating synovial joint disease characterized by increased synovial cells division, inflammation, cartilage destruction and bone deformity [1-3]. Infiltration of inflammatory cells and growth factors plays a crucial role in formation of synovial pannus [4]. The abnormal activity of immune cells results in dysregulated immune response in the inflamed synovial membrane which ultimately contributes to the cartilage destruction and bone erosion. In spite of significant therapeutic development, diagnosis of RA still remains unexplained. Hence understanding the molecular mechanism of RA, as a holistic approach, becomes a key technique for researchers to connect it with various factors like environment, stochastic, transcription factors and miRNAs. Recent investigation reports that miRNAs have the potential to become the next generation diagnostics and therapeutics. Moreover, it is attracting tremendous attention from the biological and biomedical research communities. Understanding the functioning of the miRNAs is becoming crucial for identifying the underlying role in different disease pathogenesis [5]. MiRNAs are evolutionarily conserved sequences, approximately 22 nucleotides in length, which regulates about 30% of the mammalian proteinencoding genes. Specific miRNAs when bound with target mRNAs can inhibit its expression by a variety of mechanisms [6]. This type of repression is directly dependent on sequence complementarity between seed region of miRNA and target sequence of mRNA. Partial complementarity may result in translation repression or target mRNA instability, whereas perfect complementarity between the miRNA and mRNA heteroduplex will cause target mRNA destruction [7]. MiRNAs have been identified as key regulators of major cellular processes like cell division, death, cellular metabolism, intracellular signaling, immunity, and cell movement [8-12]. Any abnormal miRNA expression will affect the above critical processes, and will therefore lead to various disorders.

Report suggests that miRNAs plays important role in inflammatory responses, cell proliferation of synoviocytes, and production of MMPs in RA [13]. Watanabe et al., (2015) reports, up regulation of miR-146a and miR-155 in the synovium, as a result of inflammatory signals, apparently plays a role in RA pathogenesis by regulating the inflammation [14]. Also, macrophages and T cells which are key regulatory molecules in RA were regulated by MiR- 146a. This miR-146a is found to be expressed in several CD3+ T cell subsets and CD79a+ B cells and it is associated with CD68+ macrophages and CD4+T cells (17). Therefore, identification of unique miRNAs that are expressed patterns in RA can be perceived as molecular diagnostic markers which can shed light in understanding the role of miRNAs in RA pathogenesis. It paves a path towards new gene therapy approaches for handling RA and other autoimmune arthritis.


  1. Devauchelle V, Marion S, Cagnard N, Mistou S, Falgarone G, Breban M, Anract P. DNA microarray allows molecular profiling of rheumatoid arthritis and identification of pathophysiological targets. Genes and immunity. 2004; 5: 597-608.
  2. Singh S, Vennila JJ, Snijesh VP, George G, Sunny C. Implying Analytic Measures for Unravelling Rheumatoid Arthritis Significant Proteins through Drug–Target Interaction. Interdisciplinary Sciences: Computational Life Sciences. 2015; 1-10.
  3. Snijesh VP, Singh S. Molecular modeling and network based approach in explaining the medicinal properties of Nyctanthesarbortristis, Lippianodiflora for rheumatoid arthritis. Journal of Bioinformatics and Intelligent Control. 2014; 3: 31-38.
  4. McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nature Reviews Immunology. 2007; 7: 429-442.
  5. Kozomara Ana, 7Sam Griffiths-Jones. "miRBase: integrating microRNA annotation and deep-sequencing data." Nucleic acids research: gkq1027. 2010.
  6. Felekkis K, Touvana E, Stefanou Ch, Deltas C. "microRNAs: a newly described class of encoded molecules that play a role in health and disease." Hippokratia. 2010: 236-240.
  7. He, Lin, Gregory J Hannon. "MicroRNAs: small RNAs with a big role in gene regulation." Nature Reviews Genetics. 2004; 522-531.
  8. Ng Raymond, Song G, Roll GR, Frandsen NM, Willenbring H. "A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration." The Journal of clinical investigation. 2012; 1097-1108.
  9. Rayner Katey J, Christine C Esau, Farah N Hussain, Allison L McDaniel, Stephanie M. et al. "Inhibition of miR-33a/b in non-human a primate raises plasma HDL and lowers VLDL triglycerides." Nature. 2011; 404-407.
  10. Zhang, Pingyu, Bill K, Liu J, Young E, Peng T, Bolshakov S, Hoffman A. et al. "MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling." Cancer research. 2012; 1751-1762.
  11. Taganov, Konstantin D, Chang KJ, Baltimore D. "NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses." Proceedings of the National Academy of Sciences. 2006: 12481-12486.
  12. Png Kim J, Halberg N, Yoshida M, Tavazoie SF. "A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells." Nature. 2012; 190-194.
  13. Nakasa, Tomoyuki, Yamasaki K, Ochi M. "A mini-review: microRNA in arthritis."Physiological Genomics. 2011: 566-570.
  14. Watanabe-Tanaka, Yoko, and Hiroshi Asahara. "The role of microRNAs in the pathogenesis of rheumatoid arthritis." Inflammation and Regeneration. 2015; 148-153.

Download PDF

Citation:Sunny JS, Snijesh VP and Singh S. Potential Role of Mirnas in Rheumatoid Arthritis. Austin Arthritis. 2016; 1(2): 1009.

Journal Scope
Online First
Current Issue
Abstract Board
Instruction for Authors
Submit Your Article
Contact Us