Autoserum Skin Tests in Autistic Patients their Mothers and in Allergic Patients

Research Article

Austin J Autism & Relat Disabil. 2016; 2(5): 1032.

Autoserum Skin Tests in Autistic Patients their Mothers and in Allergic Patients

Cardoso RR*

Department of Allergy and Immunopathology, Faculdades Integradas do Planalto Central (FACIPLAC), Medical School, Brazil

*Corresponding author:Roberto Ronald de Almeida Cardoso, Clínica de Alergia So Joaquim, Quadra 1 Bloco E Salas 301/313/314, Brasília DF, CEP 70303-900, Brazil

Received: August 09, 2016; Accepted: October 05, 2016; Published: October 06, 2016


Background & Objectives: Allergies and autism are considered distinct diseases. Allergies are frequently found among patients with autism and autism shows an increased frequency among the allergic patients. In some immunological aspects allergies and autism share similar patterns.

Methods: The Autoserum Skin Test (ASST) was used to demonstrate the presence of anti-IgE and/or anti-IgE receptor antibodies (FceRIα).

Results: The ASST demonstrated similar frequency, positives/positives and negatives/negatives, considering allergic and autistic patients. These results were different in the control group. A positive correlation had been found with the results of autistic patients and their mothers.

Interpretation & Conclusions: Autistic and allergic patients share some immunological similarities. Both differ from normal controls. It is not uncommon autistics with allergic symptoms and allergic patients with autism. If the immunological findings represent a clinical bridge between both processes, it is under discussion.

Also, it was demonstrated a possible genetic correlation between the patients with autism and their mothers. With allergic patients genetic correlation is well known.

Keywords: Allergy, Anti-IgE receptor, Autism, Auto antibodies, IgE, Skin test


Infantile autism was first described by Leo Kanner (1894-1981) in 1943 [1]. It is defined by DSM-IV criteria as a childhood behavioral and neurological disorder with onset prior to three years of age [2]. In 1978 in the United States 0,01% of the children showed autistic symptoms [3]. In 2008 this percentage increased to 0,88% [4,5]. The history of allergies comes about two thousand years ago. As to autism, its frequency is rising. Food allergies, for example, have increased about 1,2 percentage point per decade [6].

This paper attempts to demonstrate some immunological aspects common in the autism and in the allergies. We studied the presence of anti-IgE and/or anti-IgE receptor antibodies (FceRIα in both groups) through ASST procedure technique [7-9].

The diagnosis of allergy was established through the history, clinical, and routine laboratorial findings. With rhe autistics the diagnosis was clinical and based on the criteria for autistic disorder as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV) [10].

Informed consent was obtained from all subjects, their parents or guardians, for participation in the study.

Materials and Methods

To the study, a total of 251 individuals were enrolled, divided in groups as follows: