Antifungal Activity of Some Mixed Ligand Complexes Incorporating Schiff Bases

Research Article

J Bacteriol Mycol. 2020; 7(1): 1122.

Antifungal Activity of Some Mixed Ligand Complexes Incorporating Schiff Bases

Miloud MM1, El-ajaily MM2*, Al-noor TH3 and Albarki NS4

¹Department of Botany, Faculty of Science, Benghazi University, Al-abyar branch, Libya

²Department of Chemistry, Faculty of Science, Benghazi University, Benghazi, Libya

³Department of Chemistry, Ibn -Al-Haithem College of Education for Pure Science, Baghdad University, Baghdad, Iraq

4Department of Chemistry, Faculty of Science, Ajdabyia University, Ajdabyia, Libya

*Corresponding author: El-ajaily MM, Department of Chemistry, Faculty of Science, Benghazi University, Benghazi, Libya

Received: January 31, 2020; Accepted: February 20, 2020; Published: February 27, 2020

Abstract

The Schiff base (HL1), namely; [(S,Z)-2-((2-hydroxy-1-phenylethylidene) amino)-3-(4-hydroxyphenyl)propanoic acid] was synthesized by the condensation of 2-hydroxyacetophenone and L-Tyrosine Whereas, the other Schiff base (HL2), namely; (E)-4-((2-(2,4-dinitrophenyl)hydrazono)methyl)-N,Ndimethylaniline] was synthesized by refluxing 4-dimethylaminobenzaldehyde and 2,4-dinitrophenylhydrazine. The first Schiff base (HL1) is used as primary ligand, whereas, the second Schiff base (HL2) is used as secondary ligand to prepare five mixed ligand complexes with Co(II), Ni(II), Cu(II), Zn(II) and Fe(III) ions. These synthesized mixed ligand complexes were characterized by using several spectroanalytical techniques. The data reveals octahedral geometry for all the mixed ligand complexes. In addition, these compounds were also tested for their antifungal activities against Aspergillus niger, Aspergillus flavus, Altarnaria alternata, Rhizopus stolonifer.

Keywords: Schiff Bases; Mixed Ligand Complexes; Antifungal Activity

Introduction

The Schiff base compounds are commonly used as ligands in the synthesis of coordination compounds [1,2]. These compounds have an important role due to their physiological and pharmaceutical activities [3,4]. Miloud et al [5] have studied the antifungal activities of five mixed ligand complexes with a Schiff base as main ligand and 2-aminobenzoic acid as co-ligand by using agar well diffusion method. It was found that some of the complexes are most active against Aspergillus niger, Aspergillus flavus, Altarnaria alternata, Rhizopus stolonifer.

Nair et al [6] have also reported four complexes with a Schiff base formed from 3-aminobenzoic acid and indole-3-carboxaldehyde. The antimicrobial activities of these compounds were examined by diffusion method and the results confirmed that the free Schiff base is less active than its metal complexes. Three complexes of divalent metal ions with a Schiff base formed from the reaction of 4-diethylaminosalicylaldehyde and 1-(4-aminophenyl) ethanone oxime have been investigated. The results are in good agreement with square planar geometry for Ni(II) and Cu(II) complexes, while, a tetrahedral geometry for Co(II) complex [7]. The biological activity of all the compounds was examined against some selected pathogenic organisms. Andiappan et al [8] have reported a series of lanthanide complexes with a Schiff base obtained by the condensation of 2,6-diaminopyridine and anthracene-9-carbaldehyde. The Schiff base and its metal complexes were tested for their cytotoxic activity against cervical (HeLa) and human breast cancer (MCF7) cell line.

In this study, we have reported the antifungal activities of some Schiff base mixed ligand complexes of Co(II), Ni(II), Cu(II), Zn(II) and Fe(III) chelates against some fungal strains such as A. niger, A. flavus, A. alternata, R. stolonifer.

Experimental

Chemicals and physical measurements

All the chemicals and reagents used in this study were of AR grade. The characterizations such as CHN analyses, molar conductivity, magnetic moment measurements and spectral analyses of these synthesized Schiff base ligands and their mixed ligand complexes has already been reported [9]. But here we are reporting the antifungal activities of these compounds.

Synthesis of Schiff bases and their mixed ligand complexes

The Schiff base (HL1), namely; [(S,Z)-2-((2-hydroxy-1- phenylethylidene)amino)-3-(4-hydroxyphenyl)propanoic acid] was synthesized by the condensation of 2-hydroxyacetophenone and L-Tyrosine (Figure 1). Whereas, the other Schiff base (HL2), namely; (E)-4-((2-(2,4-dinitrophenyl)hydrazono) methyl)-N,N-dimethylaniline] was synthesized by refluxing 4-dimethylaminobenzaldehyde and 2,4-dinitrophenylhydrazine (Figure 2,3). The Schiff bases and their mixed ligand complexes have been reported earlier [9].