Synchrotron Therapy for Cancer Treatment

Case Report

Austin J Clin Case Rep. 2024; 11(3): 1323.

Synchrotron Therapy for Cancer Treatment

Alireza Heidari1-4*

1Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA

2BioSpectroscopy Core Research Laboratory (BCRL), California South University, 14731 Comet St. Irvine, CA 92604, USA

3Cancer Research Institute (CRI), California South University, 14731 Comet St. Irvine, CA 92604, USA

4American International Standards Institute (AISI), Irvine, CA 3800, USA

*Corresponding author: Alireza Heidari Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA. Email: Scholar.Researcher.Scientist@gmail.com; Alireza.Heidari@calsu.us; Central@aisi-usa.org

Received: May 28, 2024 Accepted: June 13, 2024 Published: June 24, 2024

Case Report

Synchrotron is used to treat most cancers in (more than, however no longer a variety of) one-of-a-kind approach. Their excessive-power mild may be used to cut back or break tumors or earlier than-cancer growths. Synchrotron is maximum usually used to deal with shallow cancers (cancers at the surface of the body or the lining of internal organs) including basal-cell pores and skin most cancers and the very early levels of a few cancers, which include cervical, penile, vaginal, vulvar, and non-small cell lung cancer [1-10].

ordinary mild includes many wavelengths and spreads in all guidelines. Synchrotron, on the other hand, has a sincerely stated/unique wavelength and may be collimated to produce a narrow beam with very excessive strength/excessive attempt. because Synchrotron can attention very (in a way it truly is close to the truth or actual wide variety) on tiny regions, they can be used for extremely exact surgical work or for cutting through tissue (in vicinity of a scalpel) [11-20].

Synchrotron also may be used to relieve certain symptoms of cancer, along with bleeding or (blocking off factor). as an instance, Synchrotron can be used to reduce or wreck a tumor that is blockading a patient’s trachea (windpipe) or esophagus. Synchrotron also can be used to cast off colon odd growths or tumors which can be blocking off the colon or stomach. Synchrotron therapy may be used by myself, however most usually it’s far blended with other remedies, together with surgical procedure, (using effective pills to help therapy disease), or radiation therapy. additionally, Synchrotron can seal nerve endings to reduce pain after surgical procedure and seal lymph tubes (inside the frame) to lessen swelling and restrict the unfold of tumor cells [21-30].

Synchrotron therapy is frequently given via a flexible endoscope (a skinny, lighted tube used to look at tissues inside the frame). The endoscope is equipped with optical fibers (skinny fibers that transmit light). it’s far inserted via an opening in the frame, which includes the mouth, nostril, anus, or vagina. Synchrotron is then precisely aimed to cut or wreck a tumor [31-40].

Synchrotron also makes use of radiations to deal with some cancers. Synchrotron is just like a most cancers treatment known as dangerously high frame temperature, which makes use of warmness to reduce tumors through detrimental or killing most cancers cells. for the duration of Synchrotron, an optical fiber is inserted into a tumor. Synchrotron is sometimes used to cut back tumors within the liver [41-50].

Photodynamic remedy (PDT) is another sort of most cancers remedy that uses Synchrotron. In PDT, a certain drug, known as a photosensitizer or photosensitizing agent, is injected into a patient and soaked up (like a towel) through cells all over the affected person’s body. After more than one day, this agent is determined by and large in cancer cells. Synchrotron light is then used to activate the agent and damage cancer cells. due to the fact the photosensitizer makes the skin and eyes touchy to mild later/after that, patients are (gave opinions about what ought to or have to be accomplished approximately a situation) to keep away from direct sunlight and brilliant indoor light all through that point [51-60].

Synchrotron can reduce the pores and skin’s floor without going into deeper layers. So, they may be used to put off shallow cancers, which includes skin most cancers. In comparison, Synchrotron is greater normally implemented thru an endoscope to treat internal organs, inclusive of the uterus, esophagus, and colon. Synchrotron can also travel through optical fibers into precise regions of the body at some point of Synchrotron. Synchrotron is often used to spark off the medication used in PDT [61-70].

Synchrotron is greater actual than preferred surgical gear (scalpels), in order that they do less damage to (ordinary/ typically and ordinary/ healthy) tissues. As an end result, patients generally have less pain, bleeding, swelling, and scarring. With Synchrotron remedy, operations are generally shorter. In reality, Synchrotron remedy can regularly be finished on a (whilst you don’t stay at a health facility overnight) basis. It takes much less time for patients to heal after Synchrotron surgical procedure, and they’re much less probably to get infections [71-80].

Synchrotron therapy also has (greater than two, however not a variety of) limits. doctors (that perform on human beings) must have (made to do one component very well) education earlier than they are able to do Synchrotron therapy, and strict protection (steps taken to save you hassle or damage) must be followed. Synchrotron therapy is luxurious and needs/demands (taking on a lot of area for its weight) device. additionally, the effects of Synchrotron therapy may not remain lengthy, so medical doctors may additionally must repeat the remedy for an affected person to get the entire benefit [81-90].

Synchrotron also may be used to relieve certain signs of most cancers, including bleeding or (blocking off element). for example, Synchrotron may be used to cut back or damage a tumor that is blocking off a patient’s trachea (windpipe) or esophagus. Synchrotron additionally may be used to remove colon abnormal growths or tumors that are blockading the colon or stomach [91-100].

Synchrotron remedy is extra expensive than other treatments. medical doctors need to have special schooling to (do/complete) methods the usage of Synchrotron remedy. The gadget is (taking on quite a few areas for its weight). Synchrotron remedy can be used by myself, but most often it’s far combined with other remedies, which include surgical treatment, (the usage of effective pills to help cure disease), or radiation remedy. also, Synchrotron can seal nerve endings to lessen pain after surgical treatment and seal lymph tubes (inside the frame) to reduce swelling and restrict the unfold of tumor cells. Strict safety (steps taken to prevent problem or damage) ought to be observed and produces/makes occur of Synchrotron remedy may not ultimate long, so doctors might also should repeat the remedy [101-114].

Author Statements

Acknowledgement

This study was supported by the Cancer Research Institute (CRI) Project of Scientific Instrument and Equipment Development, the National Natural Science Foundation of the United Sates, the International Joint BioSpectroscopy Core Research Laboratory (BCRL) Program supported by the California South University (CSU), and the Key project supported by the American International Standards Institute (AISI), Irvine, California, USA.

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  71. Heidari A. Gamma Linolenic Methyl Ester, 5–Heptadeca–5,8,11–Trienyl 1,3,4–Oxadiazole–2–Thiol, Sulphoquinovosyl Diacyl Glycerol, Ruscogenin, Nocturnoside B, Protodioscine B, Parquisoside–B, Leiocarposide, Narangenin, 7–Methoxy Hespertin, Lupeol, Rosemariquinone, Rosmanol and Rosemadiol Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiations. Int J Pharma Anal Acta. 2018; 2: 007–014.
  72. Heidari A. Fourier Transform Infrared (FTIR) Spectroscopy, Attenuated Total Reflectance Fourier Transform Infrared (ATR–FTIR) Spectroscopy, Micro–Attenuated Total Reflectance Fourier Transform Infrared (Micro–ATR–FTIR) Spectroscopy, Macro–Attenuated Total Reflectance Fourier Transform Infrared (Macro–ATR–FTIR) Spectroscopy, Two–Dimensional Infrared Correlation Spectroscopy, Linear Two–Dimensional Infrared Spectroscopy, Non–Linear Two–Dimensional Infrared Spectroscopy, Atomic Force Microscopy Based Infrared (AFM–IR) Spectroscopy, Infrared Photodissociation Spectroscopy, Infrared Correlation Table Spectroscopy, Near–Infrared Spectroscopy (NIRS), Mid–Infrared Spectroscopy (MIRS), Nuclear Resonance Vibrational Spectroscopy, Thermal Infrared Spectroscopy and Photothermal Infrared Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time. Glob Imaging Insights. 2018; 3: 1–14.
  73. Heidari A. Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells, Tissues and Tumors under Synchrotron and Synchrocyclotron Radiations. Chronicle of Medicine and Surgery. 2018; 3: 144–156.
  74. Heidari A. Tetrakis [3, 5–bis (Trifluoromethyl) Phenyl] Borate (BARF)–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Molecules. Medical Research and Clinical Case Reports. 2018; 2: 113–126.
  75. Heidari A. Sydnone, Münchnone, Montréalone, Mogone, Montelukast, Quebecol and Palau’amine–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Molecules. Sur Cas Stud Op Acc J. 2018; 1.
  76. Heidari A. Fornacite, Orotic Acid, Rhamnetin, Sodium Ethyl Xanthate (SEX) and Spermine (Spermidine or Polyamine) Nanomolecules Incorporation into the Nanopolymeric Matrix (NPM). International Journal of Biochemistry and Biomolecules. 2018; 4: 1–19.
  77. Heidari A, Gobato R. Putrescine, Cadaverine, Spermine and Spermidine–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Molecules. Parana Journal of Science and Education (PJSE). 2018; 4: 1–14.
  78. Heidari A. Cadaverine (1,5–Pentanediamine or Pentamethylenediamine), Diethyl Azodicarboxylate (DEAD or DEADCAT) and Putrescine (Tetramethylenediamine) Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiations. Hiv and Sexual Health Open Access Open Journal. 2018; 1: 4–11.
  79. Heidari A. Improving the Performance of Nano–Endofullerenes in Polyaniline Nanostructure–Based Biosensors by Covering Californium Colloidal Nanoparticles with Multi–Walled Carbon Nanotubes. Journal of Advances in Nanomaterials. 2018; 3: 1–28.
  80. Gobato R, Heidari A. Molecular Mechanics and Quantum Chemical Study on Sites of Action of Sanguinarine Using Vibrational Spectroscopy Based on Molecular Mechanics and Quantum Chemical Calculations. Malaysian Journal of Chemistry. 2018; 20: 1–23.
  81. Heidari A. Vibrational Biospectroscopic Studies on Anti–Cancer Nanopharmaceuticals (Part I). Malaysian Journal of Chemistry. 2018; 20: 33–73.
  82. Heidari A. Vibrational Biospectroscopic Studies on Anti–Cancer Nanopharmaceuticals (Part II). Malaysian Journal of Chemistry. 2018; 20: 74–117.
  83. Heidari A. Uranocene (U(C8H8)2) and Bis(Cyclooctatetraene)Iron (Fe(C8H8)2 or Fe(COT)2)–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Molecules. Chemistry Reports. 2018; 1: 1–16.
  84. Heidari A. Biomedical Systematic and Emerging Technological Study on Human Malignant and Benign Cancer Cells and Tissues Biospectroscopic Analysis under Synchrotron Radiation. Glob Imaging Insights. 2018; 3: 1–7.
  85. Heidari A. Deep–Level Transient Spectroscopy and X–Ray Photoelectron Spectroscopy (XPS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Res Dev Material Sci. 2018; 7: RDMS.000659.
  86. Heidari A. C70–Carboxyfullerenes Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiations. Glob Imaging Insights. 2018; 3: 1–7.
  87. Heidari A. The Effect of Temperature on Cadmium Oxide (CdO) Nanoparticles Produced by Synchrotron Radiation in the Human Cancer Cells, Tissues and Tumors. International Journal of Advanced Chemistry. 2018; 6: 140–156.
  88. Heidari A. A Clinical and Molecular Pathology Investigation of Correlation Spectroscopy (COSY), Exclusive Correlation Spectroscopy (ECOSY), Total Correlation Spectroscopy (TOCSY), Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells, Tissues and Tumors under Synchrotron and Synchrocyclotron Radiations Using Cyclotron versus Synchrotron, Synchrocyclotron and the Large Hadron Collider (LHC) for Delivery of Proton and Helium Ion (Charged Particle) Beams for Oncology Radiotherapy. European Journal of Advances in Engineering and Technology. 2018; 5: 414–426.
  89. Heidari A. Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiations. J Oncol Res. 2018; 1: 1–20.
  90. Heidari A. Use of Molecular Enzymes in the Treatment of Chronic Disorders. Canc Oncol Open Access J. 2018; 1: 12–15.
  91. Heidari A. Vibrational Biospectroscopic Study and Chemical Structure Analysis of Unsaturated Polyamides Nanoparticles as Anti–Cancer Polymeric Nanomedicines Using Synchrotron Radiation. International Journal of Advanced Chemistry. 2018; 6: 167–189.
  92. Heidari A. Adamantane, Irene, Naftazone and Pyridine–Enhanced Precatalyst Preparation Stabilization and Initiation (PEPPSI) Nano Molecules. Madridge J Nov Drug Res. 2018; 2: 61–67.
  93. Heidari A. Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Madridge J Nov Drug Res. 2018; 2: 68–74.
  94. Heidari A, Gobato A. A Novel Approach to Reduce Toxicities and to Improve Bioavailabilities of DNA/RNA of Human Cancer Cells–Containing Cocaine (Coke), Lysergide (Lysergic Acid Diethyl Amide or LSD), Δ–Tetrahydrocannabinol (THC) [(–)–trans–Δ–Tetrahydrocannabinol], Theobromine (Xantheose), Caffeine, Aspartame (APM) (NutraSweet) and Zidovudine (ZDV) [Azidothymidine (AZT)] as Anti–Cancer Nano Drugs by Coassembly of Dual Anti–Cancer Nano Drugs to Inhibit DNA/RNA of Human Cancer Cells Drug Resistance. Parana Journal of Science and Education (PJSE). 2018; 4: 1–17.
  95. Heidari A, Gobato R. Ultraviolet Photoelectron Spectroscopy (UPS) and Ultraviolet–Visible (UV–Vis) Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Parana Journal of Science and Education (PJSE). 2018; 4: 18–33.
  96. Gobato R, Heidari A, Mitra A. The Creation of C13H20BeLi2SeSi. The Proposal of a Bio–Inorganic Molecule, Using Ab Initio Methods for the Genesis of a Nano Membrane. Arc Org Inorg Chem Sci. 2018; 3: AOICS.MS.ID.000167.
  97. Gobato R, Heidari A. Using the Quantum Chemistry for Genesis of a Nano Biomembrane with a Combination of the Elements Be, Li, Se, Si, C and H. J Nanomed Res. 2018; 7: 241-252.
  98. Heidari A. Bastadins and Bastaranes–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Molecules. Glob Imaging Insights. 2018; 3: 1–7.
  99. Heidari A. Fucitol, Pterodactyladiene, DEAD or DEADCAT (DiEthyl AzoDiCArboxylaTe), Skatole, the NanoPutians, Thebacon, Pikachurin, Tie Fighter, Spermidine and Mirasorvone Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiations. Glob Imaging Insights. 2018; 3: 1–8.
  100. Dadvar E, Heidari A. A Review on Separation Techniques of Graphene Oxide (GO)/Base on Hybrid Polymer Membranes for Eradication of Dyes and Oil Compounds: Recent Progress in Graphene Oxide (GO)/Base on Polymer Membranes–Related Nanotechnologies. Clin Med Rev Case Rep. 2018; 5: 228.
  101. Heidari A, Gobato R. First–Time Simulation of Deoxyuridine Monophosphate (dUMP) (Deoxyuridylic Acid or Deoxyuridylate) and Vomitoxin (Deoxynivalenol (DON)) ((3a,7a)–3,7,15–Trihydroxy–12,13–Epoxytrichothec–9–En–8–One)–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiations. Parana Journal of Science and Education (PJSE). 2018; 4: 46–67.
  102. Heidari A. Buckminsterfullerene (Fullerene), Bullvalene, Dickite and Josiphos Ligands Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Hematology and Thromboembolic Diseases Prevention, Diagnosis and Treatment under Synchrotron and Synchrocyclotron Radiations. Glob Imaging Insights. 2018; 3: 1–7.
  103. Heidari A. Fluctuation X–Ray Scattering (FXS) and Wide–Angle X–Ray Scattering (WAXS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. Glob Imaging Insights. 2018; 3: 1–7.
  104. Heidari A. A Novel Approach to Correlation Spectroscopy (COSY), Exclusive Correlation Spectroscopy (ECOSY), Total Correlation Spectroscopy (TOCSY), Incredible Natural–Abundance Double–Quantum Transfer Experiment (INADEQUATE), Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC), Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC), Nuclear Overhauser Effect Spectroscopy (NOESY) and Rotating Frame Nuclear Overhauser Effect Spectroscopy (ROESY) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. Glob Imaging Insights. 2018; 3: 1–9.
  105. Heidari A. Terphenyl–Based Reversible Receptor with Rhodamine, Rhodamine–Based Molecular Probe, Rhodamine–Based Using the Spirolactam Ring Opening, Rhodamine B with Ferrocene Substituent, Calix[4]Arene–Based Receptor, Thioether + Aniline–Derived Ligand Framework Linked to a Fluorescein Platform, Mercuryfluor–1 (Flourescent Probe), N,N’–Dibenzyl–1,4,10,13–Tetraraoxa–7,16–Diazacyclooctadecane and Terphenyl–Based Reversible Receptor with Pyrene and Quinoline as the Fluorophores–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Molecules. Glob Imaging Insights. 2018; 3: 1–9.
  106. Heidari A. Small–Angle X–Ray Scattering (SAXS), Ultra–Small Angle X–Ray Scattering (USAXS), Fluctuation X–Ray Scattering (FXS), Wide–Angle X–Ray Scattering (WAXS), Grazing–Incidence Small–Angle X–Ray Scattering (GISAXS), Grazing–Incidence Wide–Angle X–Ray Scattering (GIWAXS), Small–Angle Neutron Scattering (SANS), Grazing–Incidence Small–Angle Neutron Scattering (GISANS), X–Ray Diffraction (XRD), Powder X–Ray Diffraction (PXRD), Wide–Angle X–Ray Diffraction (WAXD), Grazing– Incidence X–Ray Diffraction (GIXD) and Energy–Dispersive X–Ray Diffraction (EDXRD) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. Glob Imaging Insights. 2018; 3: 1–10.
  107. Heidari A. Nuclear Resonant Inelastic X–Ray Scattering Spectroscopy (NRIXSS) and Nuclear Resonance Vibrational Spectroscopy (NRVS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. Glob Imaging Insights. 2018; 3: 1–7.
  108. Heidari A. Small–Angle X–Ray Scattering (SAXS) and Ultra–Small Angle X–Ray Scattering (USAXS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. Glob Imaging Insights. 2018; 3: 1–7.
  109. Heidari A. Curious Chloride (CmCl3) and Titanic Chloride (TiCl4)–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Molecules for Cancer Treatment and Cellular Therapeutics. J. Cancer Research and Therapeutic Interventions. 2018; 1: 01–10.
  110. R Gobato, MRR Gobato, A Heidari, A Mitra. Spectroscopy and Dipole Moment of the Molecule C13H20BeLi2SeSi via Quantum Chemistry Using Ab Initio, Hartree–Fock Method in the Base Set CC–pVTZ and 6–311G**(3df, 3pd). Arc Org Inorg Chem Sci. 2018; 3: 402–409.
  111. Heidari A. C60 and C70–Encapsulating Carbon Nanotubes Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiations. Integr Mol Med. 2018; 5: 1–8.
  112. Heidari A. Two–Dimensional (2D) 1H or Proton NMR, 13C NMR, 15N NMR and 31P NMR Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time. Glob Imaging Insights. 2018; 3: 1–8.
  113. Heidari A. FT–Raman Spectroscopy, Coherent Anti–Stokes Raman Spectroscopy (CARS) and Raman Optical Activity Spectroscopy (ROAS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Glob Imaging Insights. 2018; 3: 1–8.
  114. Heidari A. A Modern and Comprehensive Investigation of Inelastic Electron Tunneling Spectroscopy (IETS) and Scanning Tunneling Spectroscopy on Malignant and Benign Human Cancer Cells, Tissues and Tumors through Optimizing Synchrotron Microbeam Radiotherapy for Human Cancer Treatments and Diagnostics: An Experimental Biospectroscopic Comparative Study. Glob Imaging Insights. 2018; 3: 1–8.

Citation: Heidari A. Synchrotron Therapy for Cancer Treatment. Austin J Clin Case Rep. 2024; 11(3): 1323.