Primary Malignant Melanoma of Esophagus

Special Article - Cancer Clinical Cases and Images

Austin J Clin Case Rep. 2015; 2(4): 1080.

Primary Malignant Melanoma of Esophagus

Dianbo Cao*

Department of Radiology, The First Hospital of Jilin University, China

*Corresponding author: Dianbo Cao, Department of Radiology, The First Hospital of Jilin University, China

Received: October 13, 2015; Accepted: November 04, 2015; Published: November 06, 2015

Case Presentation

A 63-years old woman presented with progressive dysphagia for 1 month, and had lost approximately 2kg in weight since the onset of his illness. Physical examination showed no abnormality. MSCT scan revealed a solid mass in the distal third of the esophagus, where local fat space around the esophagus still remained (Figure A, B). Endoscopy revealed an irregular dark endoluminal and lobulated mass suited 30-35cm from the incisors (Figure C). Endo sonography showed esophageal mass to be solid, heterogenous in echoarchitecture and arising from the deep mucosa (Figure D). The biopsy specimen suggested suspected malignant melanoma. Extensive detailed examination revealed no other skin, anal, facial or rectal lesions. The patient underwent an Ivor-Lewis esophagogastrectomy and lymph node dissection. The surgical specimen showed a 5.0 cm ×4.0 cm ×4.0cm, polypoid and pigmented lesion located in the distal esophagus. The tumor was composed of plump spindle-shaped cells with pigmented cytoplasm, prominent nuclei and numerous mitosis (Figure E). Immunohistochemical stains were positive for S-100 protein and HMB-45(Figure F). Therefore, a diagnosis of primary malignant melanoma of esophagus (PMME) was made. The patient had an uneventful recovery and was in good condition on the followup of 1 year.