Squamous Cell Carcinoma of the Colon: A Case Report and Literature Review

Case Report

Austin J Clin Med. 2015;2(1): 1023.

Squamous Cell Carcinoma of the Colon: A Case Report and Literature Review

Lannaz S*, Elomrani F, ouziane I, Mrabti H and Errihani H

Department of Medical Oncology, National Institute of Oncology, Morocco

*Corresponding author: Lannaz S, Department of Medical Oncology, National Institute of Oncology, Morocco

Received: June 06, 2015; Accepted: July 08, 2015; Published: July 11, 2015

Abstract

The majority of colorectal cancers are adenocarcinoma. Primary squamous cell carcinoma of the colon is a rare tumour, only 53 cases have been published in literature. In this paper, we report a case of a 55-year-old man with squamous cell carcinoma of the colon treated by surgery and adjuvant chemotherapy with a good evolution.

We discuss the aetiopathogenic and the therapeutic management of this rare entity.

Keywords: Squamous Cell Carcinoma; Caecum; Capsule Endoscopy; Surgery; Chemotherapy

Introduction

The Squamous Cell Carcinoma (SCC) of the colon is a very rare tumour its histogenesis and its evolutionary potential still raise questions. We don’t have enough information about the risk factors, prognosis and treatment of this cancer. Here, we report a case of SCC of the colon treated successfully with surgical resection and adjuvant chemotherapy.

Observation

A 55 years old man presented in May 2013 with rectal bleeding, weight loss and an anemic syndrome. The patient had no prior cancer history or a family history of colonic malignancy. Physical examination was unremarkable. Capsule endoscopy showed a tumour in the caecum with ulceration and stenosis (Figure 1). The biopsy of this mass revealed differentiated SCC (CK5/6+++ and CK20+). The MRI enterography showed a significant circumferential thickening of the cecal wall extended to the last ileal loop with a lymph node. CT scan of the chest, abdomen and pelvis were negative for distant metastasis. After multidisciplinary discussion, the patient underwent a right hemicolectomy; the postoperative histopathological findings were in accordance with the diagnosis of well differentiated SCC (Figure 2). The margins of the excised tissue were cancer-free with two metastastatic lymph nodes. It was classified, according to the TNM classification, as pT3N1. The patient received eight cycles of adjuvant chemotherapy with capecitabine 1000 mg/m2 orally twice daily for 14 days and oxaliplatine 130 mg/m2 with a good evolution. Currently the patient is under regular control and he is in a good health, with 12 months of follow up.

Citation: Lannaz S, Elomrani F, ouziane I, Mrabti H and Errihani H. Squamous Cell Carcinoma of the Colon: A Case Report and Literature Review. Austin J Clin Med. 2015;2(1): 1023. ISSN : 2381-9146