A Rare Case of Malignant Hemangiopericytoma in the Mandible

Case Report

J Dent App. 2014;1(2): 23-24.

A Rare Case of Malignant Hemangiopericytoma in the Mandible

Yildirim B and Shuibat A*

Gazi University, Faculty of Dentistry Department of Oral Pathology, Ankara, Turkey

*Corresponding author: Shuibat A, Department of Oral Pathology, Gazi University, Emek 65100, Turkey

Received: May 09, 2014; Accepted: July 14, 2014; Published: July 16, 2014


Hemangiopericytoma (HPC) is a rare malignant vascular tumor arising from mesenchymal cells with pericytes differentiation. HPC represents only 1% of the adult vascular neoplasms. This tumor usually occurs in the limbs and pelvis with only 5% in the oral cavity and pharynx. The histological appearance does not reliably predict the biologic behaviour of the tumor. Due to chances of late recurrence and metastasis, several studies recommended long-term follow-up. A case of malignant hemangiopericytoma in the mandible in a 24 years old female with 7 years follow up have been reported in this article.


The hemangiopericytoma is a very rare tumor in the head and neck region. The first description of this tumor goes back to Scout and Murray in 1942. The tumor takes its origin from the per capillary pericytic cells of Zimmermann. These cells are present external to the endothelial cells of capillaries and venules. They may be considered as contractile cells which wrap themselves around the capillaries and venules and serve to change the caliber of their lumens. It shows variable degree of malignant potential and recurrence [1].

HPC is primarly a tumor of adult life, it is rare in infants and children. HPCs represent only 1% of all adult vascular neoplasms and 3-5% of all soft tissue sarcomas. About 15% of all HPC occur in the head and neck; in this area the sinonasal tract is the most common site followed by Orbita and nasopharynx [2,3].

HPCs may be benign (low-grade), malignant (high grade), or may occur in an intermediate form characterized by unpredictable biologic behavior [3,4]. Distinction between low and high-grade lesions is challenging on the basis of histological parameters. Tumors with benign histologic appearance have been reported to metastase [5]. An unusual case of a malignant HPC in the right mandible have been reported.

Case Report

A 24 year-old female patient was referred to Gazi University Faculty of Dentistry Department of Oral and Maxillofacial Surgery with a chief complaint of pain and swelling in the right mandibular third molar area of 3 months duration. The medical history of the patient was unremarkable but the oral hygiene was poor. On clinical examination red, firm, pedunculated, non-tender, non-fluctuant swelling was present in the right mandibular third molar area, measuring approximately 5 cm in diameter (Figure 1a). The right mandibular third molar tooth was partially erupted.

Citation: Yildirim B and Shuibat A. A Rare Case of Malignant Hemangiopericytoma in the Mandible. J Dent App. 2014;1(2): 23-24. ISSN:2381-9049