Supplement. Transcriptional factors and description.

TFs	TF description	
EGR1	The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis.	
EGR2	The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers Sequence-specific DNA-binding transcription factor.	
EHF	This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis.	
FOXH1	Transcriptional activator.	
KLF4	Transcription factor that can act both as activator and as repressor.	
	Regulates the expression of key transcription factors during embryonic development.	
KLF5	This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes.	
	This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants.	
MAFK	Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by demonizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites.	
MZF1_5-13	Binds to target promoter DNA and functions as transcription regulator.	
	May be one regulator of transcriptional events during hemopoietic development.	
	Isoforms of this protein have been shown to exist at protein level.	
SP1	Can activate or repress transcription in response to physiological and pathological stimuli. Regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses.	
SP2	This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within sub nuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.	
SPIB	SPI1 and SPIB are members of a subfamily of ETS transcription factors.	
	ETS proteins share a conserved ETS domain that mediates specific DNA binding.	
	SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-).	
SREBF1	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway.	
TFAP2C	Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. Activates genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development.	
THAP1	DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression.	
ZNF354C	May function as a transcription repressor.