Floor of Mouth Neurofibroma: A Rare Presentation

Case Report

Austin ENT Open Access. 2020; 3(1): 1009.

Floor of Mouth Neurofibroma: A Rare Presentation

Stansfield J1*, Sharma S1, Mirza O2 and Jayaram S1

¹Fairfield General Hospital, Northern Care Alliance, Manchester, UK

²Memorial Sloane Kettering Hospital, New York City, USA

*Corresponding author: Joseph Stansfield, Ear, Nose and Throat (ENT) Surgical trainee, North West Deanery, Department of ENT, Fairfield General Hospital, Northern Care Alliance, Bury, UK

Received: October 30, 2020; Accepted: December 15, 2020; Published: December 22, 2020


Solitary sporadic neurofibromas are uncommon benign tumours of the neural sheaths of the peripheral nervous system. Solitary sporadic neurofibromas of the oral cavity and floor of mouth are extremely rare. We present the case of a 36-year-old male who presented with a 3-month history of a soft non-tender floor of mouth mass. MRI demonstrated a cystic septated lesion filling the left sublingual space. The lesion was excised via an external approach. Histology and immune assay unexpectedly demonstrated a neurofibroma.

Keywords: Sporadic neurofibroma; Floor of mouth; Case report


Neurofibromas are common benign slow-growing tumours of the peripheral nervous system; they are well-circumscribed masses and compromise, in varying amounts, of Schwann cells, perineural cells and endo-neural fibroblasts [1]. It is the most common benign tumour of the peripheral nervous system. Neurofibromas can be solitary or multiple and can form part of a generalized syndromes such as Neurofibromatosis-1 (NF1) (Von Recklinghausen Syndrome) which presents as multiple neuro-cutaneous lesions due to an autosomal dominant mutation [2]. Oral neurofibromas occur in around 4-7 % of patients with a generalized neurofibroma syndromes such as NF1 [3]. However, Solitary sporadic neurofibromas unrelated to a syndrome presenting in the floor of mouth and oral cavity are extremely rare with only a few documented cases. Clinical presentation is similar to other benign oral cavity lesions and differential diagnosis includes plunging Ranula, dermoid cyst, and thyroglossal cyst amongst others. We present the case of a 36-year-old male with a three-month history of a soft, non-tender, mass that had progressively increased in size.