Austin J Gastroenterol. 2016; 3(2): 1061.
Histopathological Analysis of the Tissue Extracted on the Expandable Electrodes after Radiofrequency Ablation of Hepatocellular Carcinoma is Important to Predicting Local Recurrence
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Japan
*Corresponding author: TToru Ishikawa, Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, 280-7 Teraji, Niigata 950-1104, Japan
Received: May 29, 2016; Accepted: June 07, 2016; Published: June 09, 2016
The study by me and my colleagues our study in the May 2012 issue of Internal Medicine reported that the histopathology of the tissue adhering to the radiofrequency ablation (RFA) probes used for hepatocellular carcinoma treatment can predict local recurrence .
RFA was first used for the treatment of HCC in humans in 1993  after extensive animal studies [3,4]. RFA with a percutaneously inserted electrode can ablate tumors more completely than other locoregional treatments, and can thus reduce the rate of local recurrence [5,6].
Complete ablation of HCC is required for prevention of local recurrence and a good prognosis . Therefore, local recurrence after successful ablation of HCC using RFA is an important issue. Tissues adherent to the radiofrequency probe after ablation can be examined pathologically and may show coagulation necrosis . Given the fact that the histopathologic analysis of tissues adhering to the RFA probe after the procedure is feasible  and that complete necrosis can be immediately detected after the treatment , the objective of the our study was to assess the value of this post-procedural histological analysis as a possible predictor of local recurrence.
We found that from the HCC tumors 3 cm in size, viable tissue was present in 6 (2.1%) of 284 specimens, and the local recurrence rates after 1 and 2 years of follow-up were 6.7% and 11.2%, respectively . Local recurrence developed significantly earlier in the viable tissue group. The recurrence rate was not significantly different based on whether transcatheter arterial chemoembolization was performed .
Herein, we would like to raise the following comments: In our study , additional aggressive treatment (such as embolization, radio-embolization, local arterial chemotherapy or systemic treatment) for patients with viable tissue can therefore improve the overall survival if histopathology of the tissue adhering to the radiofrequency ablation is viable. This approach may improve the clinical outcomes in patients with HCC who undergo treatment with RFA. Further prospective trials concerning the histological analysis of RFA are needed.
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