The Rare Occurrence of the Translocation t(8;14) in Chronic Lymphatic Leukemia: Case Report and Review of the Literature

Case Report

Ann Hematol Oncol. 2015;2(5): 1039.

The Rare Occurrence of the Translocation t(8;14) in Chronic Lymphatic Leukemia: Case Report and Review of the Literature

Coym A*, Janjetovic S, Bokemeyer C and Fiedler W

Department of Oncology and Hematology, University Medical Center Hamburg-Eppendorf, Germany

*Corresponding author: Coym A, Department of Oncology and Hematology, BMT with Section of Pneumology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

Received: April 13, 2015; Accepted: May 29, 2015; Published: June 03, 2015


Genomic aberrations in Chronic Lymphatic Leukemia (CLL) are important prognostic factors of disease progression and survival and contribute to the treatment decisions and follow-up. The most common chromosomal aberrations detected in CLL are deletions of 13q14, 11q22, 17p13 and trisomy 12. Deletions 17p13.1 and 11q22.3 are strong predictors of poor survival. We report on a rare case of CLL exhibiting the MYC translocation t(8,14)(q24;q32), which is a consistent cytogenetic finding of Burkitt lymphoma. This translocation in CLL mostly appears with other chromosomal abnormalities and is associated with more aggressive disease behavior. After review of the literature, the outcome of CLL patients with MYC translocation is discussed, where prognosis is often poor.

Keywords: Translocation t(8;14); Chronic lymphatic leukaemia; Prognosis


CLL is the most common type of leukemia in the western world and it mostly affects elderly persons, with an increasing risk proportional to age [1]. Cytogenetic analysis of CLL cells provides important diagnostic, clinical, and prognostic information, which contribute to the treatment decisions [2-4].

The most common chromosomal aberrations in CLL are trisomy 12, and deletions of: 13q, 11q, 6q, 14q and 17p [2,5,6]. It is known that 17p13.1 or 11q22.3 deletions are associated with a poor prognosis [3,5]. Translocations t(8;14)(q24.1;q32), t(8;22)(q24.1;q11), and t(2;8)(p12;q24.1), known as typical and consistent chromosomal abnormalities of Burkitt lymphoma [7], are rare events in CLL patients and are thought to be associated with poor prognosis [8,9].

Case Presentation

An 83 years old male was admitted to the hospital with a deteriorating general condition followed by presyncope with dizziness and weakness while walking. Furthermore, he complained about weight loss and fever. Routine blood investigation showed leukocytosis (40x109/l with a lymphocytosis of 5.33x109/l), anemia (8,7g/dl), and thrombocytopenia (53x109/l). An increased CRP (32mg/l) and relevant renal insufficiency (creatinine: 1,8mg/dl) were detected as well. Besides splenomegaly, physical examination showed no other abnormalities, especially no enlarged peripheral lymph nodes. Computer Tomography (CT) scan revealed enlarged mesenteric lymph nodes, in addition to splenomegaly.

Cytology of bone marrow aspiration smears showed large blast like cells, besides a small population of mature lymphocytes (Figure 1). Multiparameter flow cytometry revealed expression of CD19, CD20, CD23, CD5, CD79b antigens, implicating the diagnosis of CLL. Even though cytology showed large blast like cells flow cytometry was compatible with CLL e.g. typical B-ALL antigens such as CD10, CD34 and CD13 were not expressed.