Non-Hodgkin Lymphoma of the Tongue: New Case Report and Review of the Literature

Case Report

Ann Hematol Oncol. 2016; 3(1): 1073.

Non-Hodgkin Lymphoma of the Tongue: New Case Report and Review of the Literature

Alami EL¹*, Azami MA², Bourhafour I³, Boukir A4, Ichou M¹ and Errihani H4

¹Departments of Medical Oncology, Military Hospital Med V, Morocco

²Department of Pathology, Military Hospital Mohamed V, Morocco

³Department of Radiotherapy, National Institute of Oncology, Morocco

4Department of Medical Oncology, National Institute of Oncology, Morocco

*Corresponding author: EL Alami, Departments of Medical Oncology, Military Hospital Med V, Morocco

Received: January 25, 2016; Accepted: March 05, 2016; Published: March 10, 2016


Primary non-Hodgkin’s lymphoma (NHL) of the oral region is rare. Oral manifestations are present in 3-5% of cases of NHL.We describe a case of 70 year old female who presented with a mass lesion of tongue that was diagnosed as diffuse large B cell lymphoma. The patient was treated with 4 RCHOP chemotherapy (Rituximab 375 mg/ m2, cyclophosphamide 750 mg/ m2, doxorubicin 50 mg/m2, vincristine 1.4 mg/ m2 and prednisone 100 mg/day during 5 days; the protocol is repeated every 3 weeks) and radiotherapy (36 Gy in 20 fractions). The lesion was completely disappeared after a first cycle. She has currently remained disease free for 6 months.

Keywords: NHL; R-CHOP; Tongue


NHL: Non-Hodgkin Lymphoma; R-CHOP: Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone; MRI: Magnetic Resonance Imaging; PET: Positron Emission Tomography; FDG: 18F-Fluorodeoxyglucose; BR: Bendamustine and Rituximab


Lymphomas are malignant neoplasms of the lymphocyte cell lines. They mainly involve lymph nodes, spleen and other nonhematopoietic tissues. They are mainly classified as either Hodgkin’s or non-Hodgkin’s Lymphoma (NHL), and of either B-lymphocyte or T-lymphocyte origin.

Extra nodal lymphomas represent 20-30% of non- Hodgkin’s lymphoma (NHL), the head and neck is the second most common region for the extra-nodal lymphomas after that of gastrointestinal tract. The oral manifestations are seen in 3-5% of cases of NHL.

In this paper, we will present a case of female patient treated for non Hodgkin en lymphoma of the right lateral border of the tongue and has been successfully managed by chemotherapy and radiotherapy.

Case Presentation

A 70 year old woman, presented with a 6 month history of throat pain radiating to the right ear. The evolution was marked by the appearance of a mass of the tongue associated with a shortness of breath, dysphagia and difficulty of mastication and speech. No weight loss, night sweats or fever was reported. Her medical history was unremarkable. No medications were taken on a regular basis and the patient was a non-smoker.

Oral examinations by observation show asymmetry of the tongue. Digital palpation revealed a large sub-mucosal mass involving the right lateral border of the tongue. There was no ulceration or superficial growth on the surface of the tongue.

We note a cervical lymph-adenopathy in contralateral of the tumor, however no abdominal organomegaly was noted and the remainder of the physical examination was unremarkable (Figure 1).