Concurrent Chronic Lymphocytic Leukaemia and Hairy Cell Leukaemia after Initial Treatment for Hairy Cell Leukaemia

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Ann Hematol Oncol. 2018; 5(5): 1206.

Concurrent Chronic Lymphocytic Leukaemia and Hairy Cell Leukaemia after Initial Treatment for Hairy Cell Leukaemia

Islam MS*

1Department of Haematology, Guy’s & St Stomas Hospital, Broomfield Hospital, UK

*Corresponding author: Islam MS, Department of Haematology, Broomfield Hospital, Chelmsford, UK

Received: May 15, 2018; Accepted: May 30, 2018; Published: June 12, 2018

Keywords

CLL; HCL; Co-existence

Clinical Image

A 68 years old male was initially diagnosed with hairy cell leukaemia (HCL) in 1997 and he was treated with pentostatin with normalisation of blood count and repeat bone showed complete remission. In 2017 he presented with extreme fatigue and recurrent infections. His full blood count (FBC) showed haemoglobin (Hb)- 82g/l, white blood cell (WBC) 4.7x109/L, Neutrophils 0.3x109/L, Lymphocytes 4.1x109/L, monocytes 0.0x109/L, and platelet count 43x109/L. Peripheral blood film showed smear cells and mature lymphocytes, no other abnormal morphology.

Physical examination showed splenomegaly and palpable lymph nodes in his both axillae. Lymph node biopsy confirmed concurrent CLL (CD5, CD20, and CD23 positive) and HCL (cyclin D1, DBA. 44 & TRAP positive) with mainly CLL infiltration (Figure 1A-1H).

Citation: Islam MS. Concurrent Chronic Lymphocytic Leukaemia and Hairy Cell Leukaemia after Initial Treatment for Hairy Cell Leukaemia. Ann Hematol Oncol. 2018; 5(5): 1206.