A Case Report: Small Intestinal GIST

Case Report

J Hepat Res. 2015;2(1): 1019.

A Case Report: Small Intestinal GIST

Arun Joyati Tarafder1, Mamun–Al-Mahtab2*, Sisir Ranjan Das3, Madhusudan Shaha4, Izazul Haque5, Rezaul Karim6 and Salimur Rahman1

1Department of Hepatology, Mymensingh Medical College, Bangladesh

2Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Bangladesh

3Department of Neonatology, Dhaka Medical College, Bangladesh

4Department of Gastroenterology, North East Medical College, Bangladesh

5Department of Hepatology, Comilla Medical College, Bangladesh

6Senior Consultant & Interventional Cardiologist, Cardiac Hospital & Research Institution, Bangladesh

*Corresponding author: Mamun–Al-Mahtab, Department of Hepatology, Mymensingh Medical College, Bangladesh

Received: July 08, 2014; Accepted: March 20, 2015; Published: March 31, 2015


Gastrointestinal Stromal Tumor (GIST) is the commonest mesenchymal tumour of the gastrointestinal tract, representing 1-3% of gastrointestinal malignancies. Diagnosis is confirmed on histopathology and immunohistochemistry. Surgery remains the standard initial management for all localized GISTs. We herein report a classical case of a 60 year old male with intestinal GIST.

Keywords: GIST; Gastrointestinal stromal tumor; Malignancy


Gastrointestinal Stromal Tumor (GIST) is the most common (80%) mesenchymal tumor of the alimentary cannel, representing 1-3% of gastrointestinal malignancies [1]. GISTs are usually found in the stomach or small intestine but can occur anywhere along the GI tract and rarely have extra-GI involvement [2]. The majority of GISTs present at ages 50-70 years with no clear gender predilection [3]. GISTs are uncommonly seen in patients younger than 40, however, cases in children and young adults have been reported [4]. GISTs are thought to arise from interstitial cells of Cajal (ICC), They are typically defined as tumors whose behavior is driven by mutations in the Kit gene or PDGFRA gene [1] and recognition of KIT protein expression (CD 117) as a reliable diagnostic marker of disease.

Case Report

The patients, 60 years old man, normotensive, non-diabetic, from middle class socio-economic background presented with vague abdominal pain, repeated attack of pallor and something feeling in central abdomen. He had no history of haematemesis and or melaena, cough or breathlessness, chest pain or palpitation and urinary complains. He never experienced jaundice and his bowel habit was normal.

On clinical examination, the patient was ill looking, anaemic, well oriented and co-operative with average built and nutrition. He was not icteric and no bony tenderness, lymphadenopathy and any organomegaly. He had an ill defined mobile rounded mass about 10×8 cm at umbilical region soft to firm in consistency non tender and not fixed with overlying skin. He had no ascites. Others systemic examination revealed no abnormality.

Hematological investigations revealed haemoglobin 8 gm/dl, ESR -80mm/1st hour, platelets 350×109 /L, total count of WBC 6000/mm3. Peripheral blood film showed hypochromic and and normocytic red blood cells, mature WBC and normal platelets count (Figure 1).

Citation: Tarafder AJ, Mamun–Al-Mahtab, Das SR, Shaha M and Haque I, et al. A Case Report: Small Intestinal GIST. J Hepat Res. 2015;2(1): 1019. ISSN:2381-9057