The Potent Antioxidant Alpha Lipoic Acid

Special Article - Natural Products

J Plant Chem and Ecophysiol. 2017; 2(1): 1016.

The Potent Antioxidant Alpha Lipoic Acid

El Barky AR1*, Hussein SA2 and Mohamed TM1

1Department of Biochemistry, Tanta University, Egypt

2Department of Biochemistry, Benha University, Egypt

*Corresponding author: Amira Ragab El Barky, Department of Biochemistry, Faculty of Science, Tanta University, Egypt

Received: September 19, 2017; Accepted: October 13, 2017; Published: October 25, 2017


Natural products may be alternative therapies for many diseases. Alphalipoic acid is a short-chain fatty acid, which contains sulfur in their structure. It is a potential antioxidant. Both of alpha lipoic acid and its reduced form have been shown to possess anti-oxidant, cardiovascular, cognitive, anti-ageing, detoxifying, anti-inflammatory, anti-cancer, and neuroprotective pharmacological properties. So, this article review aimed to highlight the potential role of alpha lipoic acid as an antioxidant that could be helped with treating many different diseases such as diabetes, peptic ulcer, epileptic, cardiovascular and cystinuria diseases.

Keywords: Diabetes; Alpha-lipoic acid; Cardiovascular disease; Alzheimer’s disease


ALA: Alpha-Lipoic Acid; BMI: Body Mass Index; CAT: Catalase; DM: Diabetes Mellitus; L-MDA: L-Malonaldehyde; STZ: Streptozotocin; TAG: Triacylglycerol; GPx: Glutathione Peroxidase; SOD: Superoxide Dismutase


Alpha Lipoic Acid (ALA), is a potent antioxidant, it possesses a wide array of the metabolic benefits including antiobesity, glucose lowering, insulin-sensitizing, and lipid-lowering effects [1]. α-Lipoic Acid (ALA) is a potent antioxidant that exists in our diets, it shows a great capacity when given natural or synthetic drug [2].

ALA is a short-chain fatty acid, which contain sulfur in their structure. There are two forms of ALA, the R form is the main biological active form that is produced by the body while the S form is produced from chemical manufacture and is not biologically active [3]. ALA is reduced to Dihydrolipoic Acid (DHLA). DHLA has a unique characteristic as free radical scavenging and amending oxidative stress and inflammatory pathways [3].

Alpha lipoic acid and DHLA have been shown to possess antioxidant, cardiovascular, cognitive, anti-ageing, detoxifying, antiinflammatory, anti-cancer, and neuroprotective pharmacological properties [4].


• Natural products may be alternative therapies for many diseases. They can be consumed in large daily amounts without any side effect.

• Alpha-Lipoic Acid (ALA) is a natural antioxidant compound.

• ALA has been shown to decrease symptoms of the patient suffering from many diseases.

The Chemical Structure of α-Lipoic Acid

Alpha Lipoic Acid (ALA); is also known thioctic acid, which composed of eight-carbon disulfide containing a single chiral center (Figure 1). Four distinct antioxidant actions of LA and DHLA have been observed: Reactive Oxygen species (free radical) scavenging activity, Capacity to regenerate endogenous antioxidant such as glutathione, vitamin C, and vitamin E, metal chelating activity and repair of oxidized proteins [5].

Citation: El Barky AR, Hussein SA and Mohamed TM. The Potent Antioxidant Alpha Lipoic Acid. J Plant Chem and Ecophysiol. 2017; 2(1): 1016.