Development of Cuboidal Nanomedicine by Nanotechnology

Review Article

Austin J Nanomed Nanotechnol. 2014;2(4): 1023.

Development of Cuboidal Nanomedicine by Nanotechnology

Basavaraj K Nanjwade*1, Yallappamaharaj R Hundekar2, Meghana S Kamble3 and Teerapol Srichana4

1Department of Pharmaceutics, Omer Al-Mukhtar University, Libya

2Department of Pharmaceutics, KLE College of Pharmacy, India

3Department of Pharmaceutics, P. E. Society's Modern College of Pharmacy, India

4Department of Pharmaceutics, Prince of Songkla University, Thailand

*Corresponding author: Basavaraj K Nanjwade, Department of Pharmaceutics, Omer Al-Mukhtar University, Tobruk, Libya

Received: May 26, 2014; Accepted: May 28, 2014; Published: May 29, 2014


When amphiphilic lipid systems are placed in aqueous environment that will formed self-assembled nanostructured dispersed particles which are expressed as "Cubosomes" whose size ranges from 10-500 nm in diameter and they appear like dots square shaped, slightly spherical in the form of bicontinuous cubic liquid crystalline phase. The discovery of cubosomes is unique story and spans in the field of food science, biological membranes, differential geometry and digestive process. Cubosomal drug delivery system is great potential in melanoma therapy owing to their potential advantage. Recently the research interesting is inducing on cubosomes due to their thermodynamically stable cubic structure, biodegrability of lipids, the ability of encapsulating hydrophobic, hydrophilic, amphiphilic substances is an excellent candidate for targeting and controlled release of drugs, proteins etc. The review article includes manufacturing techniques, characterisation, and applications of cuboidal drug delivery system.

Keywords: Cubosomes; Cubic phase; Bicontinuous; Biodegrability; Controlled release


Cubic liquid crystals are physically looks transparent and isotropic phases that are stable in excess water and show a unique system for the production of pharmaceutical dosage forms. The liquid crystals of cubic phase are used in the controlled release of selected water and oil soluble molecules [1].

Cubosomes are bicontinuous cubic liquid crystalline materials are active ingredients because they give the unique structural ends to control release applications [2]. Cubosomes are vesicle derivatives [3], formed by the mixture of phospholipid (glycerol monooleate) and non-ionic surfactant (poloxamer 407- block copolymers of polyoxyethylene polyoxypropylene) in aqueous media by applying high energy dispersion such as sonication and homogenization, after the formation of cubosomes the dispersion is formulated into a product and then applied to a substrate of interest usually body tissue [4], due to the formation of vesicles the stability of system remains in the interested area (figure 1) [5].