Atypical Localization of Grossly Calcified Dysembryoplastic Neuroepithelial Tumor (DNT): Case Report

Special Issue - Neurosurgery

Austin Neurol & Neurosci. 2017; 2(1): 1016.

Atypical Localization of Grossly Calcified Dysembryoplastic Neuroepithelial Tumor (DNT): Case Report

Hakan E¹*, Ahmet HK1,2, Bilal K³, Aziz Y4 and Erol T5

¹Yeni Yuzyil University Gaziosmanpasa Hospital, Department of Neurosurgery, Turkey

²Gelisim University Academy of Health Sciences, Turkey

³Maltepe University, Department of Neurosurgery, Turkey

4Ethica Incirli Hospital, Department of Neurosurgery, Turkey

5Professor of Neurosurgery, Private Consultant, Turkey

*Corresponding author: Hakan Erdogan, Yeni Yuzyil University Gaziosmanpasa Hospital, Department of Neurosurgery, Istanbul, Turkey

Received: April 14, 2017; Accepted: April 27, 2017; Published: May 04, 2017


Background: Dysembryoplastic Neuroepithelial Tumors (DNTs) are typically located within supratentorial cortex, often in the temporal lobe. They are frequently present with intractable epilepsy in children and young adults.

Case Report: In our study we report a case of 31-year-old male patient with headache and ataxia during the last six months. His neurological examination revealed no deficit. A right cerebellar mass was detected on his Magnetic Resonance Imaging (MRI). After total resection of the tumor, he was discharged from the hospital on the 10th day of the postoperative period uneventfully. Histological assessment revealed oligodendrocyte-like cells in a microcystic mucinous interstitial background containing “floating” neurons, diagnostic of DNT. In addition, immunohistochemical profile of the neoplasm has supported the diagnosis of DNT.

Conclusion: The present case has unique findings because of the location and gross calcification of the tumor. Only nine cases of cerebellar DNT have been reported in the literature. To our knowledge, both findings in the same tumor have not been reported so far.

Keywords: Dysembryoplastic neuroepithelial tumor; Atypical localization; Gross calcification


DNTs are benign tumors of the supratentorial cortex, mostly located in the temporal lobe and they usually present with epileptic seizures in children and young adults [1]. Few studies have reported extracortical locations of DNT, such as cerebellum, brainstem, pericallosal region, septum pellucidum, caudate nucleus, and intraventricular region [2-5]. Secondary germinal layers were thought to be related to these uncommon locations, in accordance with hypothesis of DNT histogenesis [1]. To our knowledge, this is the tenth case of cerebellar DNT, and the first to have massive widespread psammomatous calcification.

Case Report

A 31-year-old man presented with headache and truncal ataxia persisting for the last 6 months. Magnetic Resonance Imaging (MRI) revealed a well countered, heterogenously enhanced mass with 35×45×56 mm dimensions and signal void areas resembling hemorrhage located in the right cerebellar hemisphere which was hypointense on T1-weighted images and hyperintense on T2- weighted images (Figure 1a-d).