Review of Avitaminosis Fever and Its Clinical Significance

Review Article

Ann Nutr Disord & Ther. 2019; 6(1): 1055.

Review of Avitaminosis Fever and Its Clinical Significance

Benjamin Y Lee1,3*, Julia H Bai BS², Zhengya LI³ and Yanrong WANG³

¹Department of Biochemical Genetics/Pediatrics, Louisiana State University Health Sciences Center in Shreveport (LSUHSC-S), USA

²Department of Epidemiology, Texas A & M University, USA

³Associates of Uncle Ben’s Clinic, Uncle Ben’s Clinic at Xiaoshawo village in the west suburban area of Tianjin City, China

*Corresponding author: Benjamin Y Lee, Department of Biochemical Genetics/Pediatrics, Louisiana State University Health Sciences Center in Shreveport (LSUHSC-S), 1501 Kings Hwy, Shreveport, LA 71130, USA

Received: January 18, 2019; Accepted: February 22, 2019; Published: March 01, 2019


Avitaminosis fever is caused by minimal storage or maximal consumption of B vitamins, especially thiamin, riboflavin or niacin inside human body. They were often found after prolonged ultra-heavy labor and hunger. Berberi fever was most important, not rare and fatal, usually associated with random combinations in a great mess of severe signs and symptoms from multiple organs and endocrine glands controlled by autonomic nervous system causing very queer,. complex, complicated clinical manifestations, which made the diagnosis very difficult and confused. It should be diagnosed collectively as autonomic nervous system dysfunction or crisis, briefly as dysautonomia. The dramatic therapeutic effect of parenteral thiamin on dysautonomia remind people that it may be a very powerful physiologic super antibiotic in eliminating microbial infections regardless pathogen and severity as observed. It may be also a powerful antitumor agent and had been successfully tried in cyst, lipoma, osteosarcoma, and lyphoma. Ariboflavinosis fever was milder and commonly found in pediatric especially during winter and spring. It often associated with erythematous patches. Pellagra fever was found in two cases.

Keywords: Ariboflavinosis fever; Avitaminosis fever; Beriberi fever; Common cold; Dysautonomia; Embolism; Furuncle; Pellagra fever; Thromboses; Viral infection


Fever is a common clinical sign in many kinds of diseases. The most common cause is malnutrition related infections, such as tuberculosis, pneumonia, or gastrointestinal disorders. Their treatments invariably depend on antibiotics. However, fever could be resulted directly from severe deficiency of some nutrients themselves, such as berlberi fever, ariboflavosis fever, or pellagra fever. They were observed in a population with terribly hard labor and hunger, such as in a labor camp 1958-1962 before and during Nationwide Hunger [1]. This paper introduces the follows: 1. Avitaminosis fevers due to deficiency of thiamin, riboflavin, or niacin themselves might be found in cases with prolonged severe labor and hunger 2. Thiamin deficiency fever was very violent and often involved multiple organs and endocrine glands from different systems and often leading to death. Its diagnosis was very complicated and confused, which could be collectively termed as dysautonomia 3. High dose of parenteral thiamin could surely bring down high fever in avitaminosis fever, however unexpectedly, high fever due to different microbial infections including virus and bacteria or even lymphoma [2] could be normalized with it. Therefore, high dose thiamin injection may be a physiologic anti-microbial agent comparable or superior to the current best antibiotics.

Thiamin deficiency fever

Accidental finding: Mr. GONG KM was a 26-year-old laborer who suffered from frequent cramps and persisting numbness of the extremities for 3 years. After arduous labor for several days, he experienced sudden onset of high fever and severe headache as if hit on the head with a hammer on a day of Feb 1959. He complained also tightening of the chest. The temperature rose to 41°C even under penicillin from the beginning and followed by herbal medicine. Respiratory difficulty developed and asphyxia resulted as if his chest were bandaged by multiple wide bands. According to the successfully relieving arm moving failure in a carpenter with parenteral thiamin 10 mg, same medicine of same dose was injected. Asphyxia and headache dramatically improved. Surprisingly, the high temperature decreased to 38.5°C after one hour although it returned to 39.5°C two hours later. Another 50 mg of thiamin was then injected and the temperature normalized with full clinical recovery. Therefore, thiamin deficiency fever was diagnosed accidentally (Figure 1).