Letter to the Editor
Austin Oncol. 2016; 1(2): 1008.
Department of Pediatrics, TTUHSC, Amarillo, USA
*Corresponding author: Vijay G Linga, Department of Pediatrics, TTUHSC, Amarillo, USA
Received: June 27, 2016; Accepted: June 28, 2016; Published: June 30, 2016
The two studies with large population and robust clinical data identified many variants of ANGPTL4 and their association with lower risk of coronary artery disease [1,2]. ANGPTL4 protein has many functions like lipid and glucose metabolism, angiogenesis, tumorigenesis, kidney diseases, energy homeostasis, wound healing and cell differentiation . The N terminal end of the protein is coiled - coiled region involved in the lipid metabolism . The C terminal end of the protein fibrinogen-like domain involved in vascular permeability, and regulates ROS (reactive oxygen species) level to promote tumorigenesis . In both studies there are inactivating mutations at the fibrinogen-like domain of ANGPLT4, implying possible decreased risk for cancer. Even though the ANGPTL4 is not a initiator of cancer, it has very important role in tumor grade , cancer invasion , cancer metastasis , poor survival  and as diagnostic marker . In both large studies there is opportunity to better characterize the role of ANGPTL4 and its variants in cancer.
- Dewey FE, Gusarova V, O’Dushlaine C, Gottesman O, Trejos J, Hunt C, et al. Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease. N Engl J Med. 2016; 374: 1123-1133.
- Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med. 2016; 374: 1134-1144.
- Zhu P, Goh YY, Chin HF, Kersten S, Tan NS. Angiopoietin-like 4: a decade of research. Biosci Rep. 2012; 32: 211-219.
- Garner JM, Ellison DW, Finkelstein D, Finkelstein D, Ganguly D, Du Z, et al. Molecular Heterogeneity in a Patient-Derived Glioblastoma Xenoline Is Regulated by Different Cancer Stem Cell Populations. PloS one. 2015; 10.
- Verine J, Lehmann-Che J, Soliman H, Feugeas JP, Vidal JS, Mongiat-Artus P, Belhadj S. Determination of angptl4 mRNA as a diagnostic marker of primary and metastatic clear cell renal-cell carcinoma. PLoS One. 2010; 5.