Intravitreal Bevacizumab Injections Can Release Vitreomacular Adhesions in Eyes with Persistent: Diabetic Macular Edema and Focal Vitreomacular Adhesions

Rapid Communication

J Ophthalmol & Vis Sci. 2016; 1(1): 1001.

Intravitreal Bevacizumab Injections Can Release Vitreomacular Adhesions in Eyes with Persistent: Diabetic Macular Edema and Focal Vitreomacular Adhesions

Al Judaibi RM¹, Al Shamsi H¹ and Ghazi NG1,2*

¹Vitreoretinal Division, King Khaled Eye Specialist Hospital, Saudi Arabia

²The Department of Ophthalmology, University of Virginia, Charlottesville, USA

*Corresponding author: Nicola G. Ghazi, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE

Received: January 22, 2016; Accepted: February 12, 2016; Published: February 22, 2016

Abstract

Purpose: To report cases of persistent Diabetic Macular Edema (DME) with focal Vitreomacular Adhesions (VMA) that responded to Intravitrealbevacizumab (IVB) injection with separation of the VMA and complete or significant resolution of DME.

Methods: Five eyes of five patients were diagnosed with persistent DME and VMA based on typical clinical, angiographic, and spectral-domain Optical Coherence Tomography (OCT) findings. A trial of IVB was attempted prior to Proceeding with Pars Planavitrectomy (PPV) to address the VMA.

Results: Prior to initiation of IVB therapy, all 5 eyes had cystoid macular edema with perifoveal vitreous separation and unifocal point VMA at the fovealcenter by SD-OCT. Following one to four injections all the eyes showed complete separation of the VMA and complete or significant resolution of DME.

Conclusions: A trial of intravitreal therapy, such as IVB, should be attempted in eyes with persistent DME and focal VMA before proceeding to PPV.

Keywords: Diabetic macular edema; Intravitrealbevacizumab; Vitreomacular traction

Abbreviations

DME: Diabetic Macular Edema; VMA: Vitreomacular Adhesions; CMT: Central Macular Thickness; V/A: Visual Acuity; IVB: Intravitrealbevacizumab; PPV: Pars Planavitrectomy; SD_OCT: Spectral-Domain Optical Coherence Tomography; anti-VEGF: Anti- Vascular Endothelial Growth Factor; No.: Number; IVAI: Intravitrealavastin Injections; μm: Microns

Introduction

DME is one of the most common causes of impaired vision in diabetic patients [1]. It is thought that the vitreous plays an important role in DME in some patients through Vitreomacular Adhesion/ Traction (VMA/VMT) and likely other mechanisms [2]. Pars Planavitrectomy (PPV), an invasive procedure, has been used in cases of persistent DME secondary to VMT [3,4]. However, its role remains controversial. Intravitreal Injection Of Bevacizumab (IVB), an anti- Vascular Endothelial Growth Factor (anti-VEGF) agent, shows an increasing evidence for a beneficial effect in treating DME in general [1,5]. However, in eyes with VMA the role of anti-VEGF agents is less well defined [3].

We have previously shown that eyes with persistent DME and VMA may have focal or plaque VMA [2]. It is our impression that focal VMA may resolve with intravitreal injections without the need for PPV. We report 5 such eyes herein.

Materials and Methods

We report five eyes of five patients that were diagnosed with persistent DME and VMA following focal laser therapy based on typical clinical, angiographic, and Spectral-Domain Optical Coherence Tomography (SD-OCT, Spectralis, Heidelberg, Germany) findings. A trial of IVB was attempted prior to proceeding with (PPV) to address the VMA. Each eye received IVB (1.25mg/0.05ml) using sterile ophthalmic techniques. SD-OCT was performed for every eye at baseline prior to injections and then at each follow up visit.

Results

The age of the patients ranged from 54 to 73 years (mean= 61.8 years). All patients were females except for one. The follow up ranged from two months to 14 months (mean=8 months). The baseline Visual Acuity (VA) ranged from 20/300 to 20/30 (median= 20/100) and the Central Macular Thickness (CMT) ranged from 444 to 688 μm (mean=569.4). All eyes disclosed cystoid macular edema with perifoveal vitreous separation and a focal adhesion of the posterior hyaloid at the fovea on SD-OCT. Following one to four injections of IVB (mean=2.8), SD-OCT showed complete separation of the VMA in all eyes with complete or significant resolution of the intraretinal fluid. The VA and CMT at last follow up ranged from 20/200 to 20/40 (median =20/60) and 191 to 427 μm (mean=312.6) respectively (Table 1) (Figure 1&2).