Review on Niosomes

Review Article

Austin Pharmacol Pharm. 2018; 3(2): 1016.

Review on Niosomes

Sanklecha VM1*, Pande VV1, Pawar SS1, Pagar OB1 and Jadhav AC2

1Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon, India

2Department of Pharmaceutics (PG), Government College of Pharmacy, Aurangabad, India

*Corresponding author: Sanklecha VM, Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon, 423603, India

Received: April 23, 2018; Accepted: May 22, 2018; Published: May 29, 2018


Vesicular medication delivery system, for example, Niosome is a novel medication delivery system, in which the solution is enclosed in vesicle which is made by Non-ionic surfactant. The niosomes provides several important advantages over conventional drug therapy. Structurally, niosomes are similar to liposomes, in that they are also made up of a bilayer. However, the bilayer in the case of niosomes is made up of non-ionic surface active agents rather than phospholipids as seen in case of liposomes. Niosomes tackled the issue of insolubility, instability, low bioavailability and fast debasement of medications. This paper overviews the method of preparation of Niosomes along with applications in pharmaceutical areas.

Keywords: Niosomes; Method of preparation; Evaluation study; Application of Niosomes.


Niosomes are a novel drug delivery system, which entrapped the hydrophilic drug in the core cavity and hydrophobic drugs in the non-polar region present within the bilayer hence both hydrophilic and hydrophobic drugs can be incorporated into niosomes [1]. The niosomes are ampiphillic in nature, in which the medication is encapsulated in a vesicle which is made by non- ionic surfactant and hence the name niosomes. The niosomes size is a very small and microscopic [2]. The first niosome formulations were developed and patented by L’Oreal in 1975. In the presence of proper mixtures of surfactants and charge inducing agents from the thermodynamically stable vesicles. Niosomes are mostly studied as an alternative to liposomes because they alleviate the disadvantages associated with liposomes [3]. Niosomes overcome the disadvantages associated with liposomes such as chemical instability. Chemical instability of liposomes is due to their predisposition to oxidative degradation and variable purity of phospholipids. The main purpose of developing niosomal system is chemical stability, biodegradability, biocompatibility, chemical stability, low production cost, easy storage and handling and low toxicity [4,5]. Niosomes can be administrated through various routes such as oral, parenteral, topical. Niosomes are used as a carrier to deliver different types of drugs such as synthetic and herbal, antigens, hormones and other bioactive compounds [6,7,8]. This article presents some Salient features of niosomes along with an overview of the preparation techniques and the current applications of niosomes in encapsulation and delivery of bioactive compounds.

Salient features of niosomes [2,9,10]