Outcome of Breast Cancer after 10-15 Years Follow up

Research Article

Austin Surg Oncol. 2019; 4(1): 1014.

Outcome of Breast Cancer after 10-15 Years Follow up

Essam Elshiekh MD, Ahmed Elghazaly MD, Tarek Salah, Mohamed Ibrahim MD

Department of Surgical Oncology, Tanta Cancer Center, Egypt

*Corresponding author: Elshiekh Essam, Department of Surgical Oncology, Tanta Cancer Center, Egypt

Received: November 25, 2019; Accepted: December 28, 2019; Published: December 31, 2019

Abstract

Background: Breast cancer is the most common malignancy diagnosed in female, it was estimated that new cancer cases and cancer deaths were 1.3 million and 327,000 every year. Breast cancer is the most malignant type in females affecting 1 in every 8 female, it affect old age starting from above 50 years old but may affect also young age. Women undergone surgery or neoadjuvant treatment followed by surgery must be under follow up for a long time to detect any recurrence or metastases or even the development of 2nd primary.

Materials and Methods: Retrospective study done at Tanta cancer center and general surgery department, faculty of medicine. Fayoum University between start of 2004-2009.

Results: 170 patients collected between 2004-2009 with the age at diagnosis was 27-71 years and median age is 49 years old of patients, 90 was premenopausal while 80 was postmenopausal patients.

All patients undergone follow up regularly according to schedule by routine visits. Local recurrence detected in 10 cases with liver metastases in 10 cases and pulmonary metastases in 10 cases with 41 patients died by end of 15 years mainly postmenopausal.

Conclusion: The use of regular and closed follow up with definite schedule is of great value for detecting any progress development of local recurrence, distant recurrence or even the development of another primary.

Keywords: Breast Cancer; Follow Up; Outcome; Recurrence

Abbreviations

IDC: Infiltrating Duct Carcinoma; ILC: Infiltrating Lobular Carcinoma; MRM: Modified Radical Mastectomy; CBS: Conservative Breast Surgery; LVI: Lymph Vascular Invasion; PNI: Peri Neural Invasion; LN: Lymph Node; UOQ: Upper Outer Quadrant; LOQ: Lower Outer Quadrant; ER: Estrogen Receptors; PR: Progesterone Receptors; BC: Breast Cancer; DFS: Disease Free Survival; OFS: Overall Free Survival.

Introduction

Breast cancer is the most common malignancy diagnosed in female [1]. Worldwide, it was estimated that new cancer cases and cancer deaths were 1.3 million and 327,000 every year [2].

Breast cancer is a type of cancer that starts in the breast. Cancer starts when cells begin to grow out of control. Breast cancer is the most malignant type in females affecting 1 in every 8 females worldwide, it can affect any age with most of types on old age starting from above 50 years old. Many women are wishing and excited to be finished with breast cancer treatment. But it can also be a time of worry, being afraid of recurrence of cancer again [3].

Women undergone surgery or neoadjuvant treatment followed by surgery must be under follow up for a long time to detect any recurrence or complications or even the development of 2nd primary.

All patients must have scheduled for investigations either in clinical examination or radiological and laboratory investigations [4].

Material and Methods

170 patients that undergone examination and diagnosis at surgical department, Tanta cancer center and General surgery department, Faculty of medicine, Fayoum University, Egypt, in the period of 2004-2009 was retrospectively collected with their full data as regard the age, pre and postmenopausal status, method of diagnosis, type of surgery done, neoadjuvat treatment and adjuvant treatment, hormonal therapy taken post-operative and development of recurrence either loco regional or distant.

All patients collected during this period treated with surgery either by Conservative Breast Surgery (CBS) or Modified Radical Mastectomy (MRM), those undergone neoadjuvant treatment were included in this study with all patients collected followed up for 10-15years with regular follow up by regular visits and whom missed were phoned to evaluate their status, the follow up was by clinical examination by oncology physician with radiological examination and laboratory needed, all patients under gone ultrasound of abdomen and pelvis for all patients with chest X-ray as regular and CT chest when suspected metastasis in X-ray and bone scan only done during follow up for patients with bony pain or complain and mammographic examination done for all patients regularly every 6months during the 1st two years after surgery and adjuvant then annually after that in both patients undergone MRM or CBS together with chest X-ray and Ultrasound abdomen and pelvis .

Results

170 patients was collected on study done at Tanta cancer center and faculty of medicine, Fayoum university between 2004-2009 with the age at diagnosis was 27-71 years and median age is 49 years old of patients, 90/170 ( 53%) was premenopausal while 80/170 (47%) was postmenopausal patients.

Of those patients all of them undergone mammographic examination with the size of tumor ranged between 2*1cm-5*4cm (all patients was T1&T2), with pathological diagnosis was by FNAC (fine needle aspiration cytology) 130/170 patients (76.48%), true cut biopsy in diagnosis was in 10/170 patients (5.88%) and by lumpectomy 30/170 patients (17.64%) (Figure 1).