The Use of ROTEM in Liver Transplant Surgeries: A Luxurious Option or a Necessity?!

Letter to Editor

Blood management in liver transplant surgeries can be challenging. In this article I will address some of the strenuous challenges related to blood management in this patient population and discuss the use of rotational thromboelastometry (ROTEM) to mitigate these challenges.

It is well known that patients with liver disease have a rebalanced hemostasis due to the impaired synthesis of both the coagulation factors and pro-coagulant factors. Interestingly, some studies demonstrated an increased endogenous thrombin potential (ETP) in patients with liver cirrhosis [1]. Hence, it is now well known that this group of patients requires special attention when it comes to blood management.

For many years, international normalized ratio (INR) has been used by clinicians to evaluate the hemostatic activity, or as a predictor of bleeding in patients with liver disease. INR is one of the commonly used conventional coagulation assay that has been developed to standardize warfarin monitoring across laboratories. This simple test has many limitations that make it an extremely poor predictor of bleeding in this group of patients. For instance, INR is designed to test the extrinsic and common coagulation pathway factors (i.e Factor VII, X, V, II, and fibrinogen). INR does not take into account the effect of the endogenous anticoagulants such as protein C and protein S which are also reduced in patients with liver disease. Therefore, INR provide only limited information about the hemostatic activity [2].

The practise of transfusing plasma to correct (normalize) INR prior to invasive procedure in liver disease patients is an exercise of futility. In patients with minimally elevated INR (1.1 – 1.8), transfusing plasma to correct INR resulted in median change of INR of 0.07 only. A significant change in INR was only observed when INR is above 5 [3,4]. In their most recent guidelines, the society of interventional radiology recommended that INR is not applicable in patients with liver disease who are attending low risk interventional radiology (IR) procedure. The society also recommended that INR of <2.5 is acceptable for liver disease patients attending high risk IR procedures [5].

Patients undergoing liver transplant surgeries are exposed to an incredibly challenging hemostatic environment and blood management in these patients is crucial. Depending on conventional coagulation testing (INR and PTT) to guide blood management in these patients results in an inappropriate transfusion of red cells and plasma and therefore increasing the risk of adverse transfusion reactions as well as volume overload [6]. One of the perhaps not widely known fact about blood transfusion is that the cost of delivering a unit of red cells to a patient can range from 522 to 1183 US dollars, and the cost of delivering a unit of plasma is approximately 409 US dollars [7].

Newer technologies like ROTEM have been proven to be associated with significantly reduced amount of blood product transfusion in bleeding patients. Thromboelastography (TEG) is another older viscoelastic testing that can also be used in this population. However, compared to TEG, ROTEM provides additional information about the entire hemostatic activity [8]. ROTEM is a point of care viscoelastic testing that is performed on whole blood samples collected in trisodium citrate tube (the regular blue top coagulation tube). There are several assays that can be performed on ROTEM, such as EXTEM and FIBTEM. ROTEM results are demonstrated in graph that shows both the coagulation process and fibrinolytic activity. The graph comprises of different parameters as shown in the (Figure 1). The shape of ROTEM graph can indicate several coagulation abnormalities. Therefore, an appropriate blood product can be transfused accordingly.

    


    


    Figure 1: Illustration of the graphical representation of ROTEM results with comparison with TEG.