Treatment of Familial Nevus Fusco-caeruleus Zygomaticus with Q-switched Alexandrite Laser

Short Communication

Austin J Dermatolog. 2014;1(4): 1020.

Treatment of Familial Nevus Fusco-caeruleus Zygomaticus with Q-switched Alexandrite Laser

Zuo YG* and Wang JB

Department of Dermatology, Chinese Academy of Medical Sciences, China

*Corresponding author: Ya-Gang Zuo, Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No 1, Shuaifuyuan Hutong, Dongcheng District, Beijing, China

Received: August 18, 2014; Accepted: September 11, 2014; Published: September 15, 2014


Nevus Fusco-caeruleus zygomaticus; Familial; Q-switched alexandrite laser


NFZ: Nevus Fusco-caeruleus Zygomaticus; FNFZ: Familial Nevus Fusco-caeruleus Zygomaticus; ABNOM: Acquired Bilateral Nevus of Ota-like Macules; Nd:YAG: Q-switched Neodymium: Yttrium- aluminum -garnet; QSAL: Q-switched Alexandrite Laser; PIH: Post-inflammatory Hyperpigmentation

Nevus Fusco-caeruleus zygomaticus (NFZ) is characterized by the bilateral occurrence of small, circumscribed, speckled, or confluent blue-brown pigmentation on typical locations of malar regions or temples, upper eyelids and root and alae of the nose [1]. It is very common in Asian. NFZ is also termed as nevus of Hori and acquired bilateral nevus of Ota-like macules (ABNOM) [2]. Recently, familial NFZ (FNFZ) was reported in a Chinese family, comprising 7 affected individuals out of 25 family members spread over four generations, in accordance with an autosomal dominant mode of inheritance [2].

The following lasers have been introduced with various clinical outcomes for the treatment of NFZ: the Q-switched neodymium: yttrium-aluminum -garnet (Nd: YAG) laser [3,4]), the Q-switched ruby laser [5], and the Q-switched alexandrite laser (QSAL) [6,7]. Our previous study and another report [8,9] showed that QSAL is effective and safe for the treatment of NFZ in Asian people. Here, we report a case of FNFZ with two affected individuals in two generations who were treated successfully with QSAL.

A 22-year-old female presented with small brown speckled spots on the bilateral zygomatic area (Figure 1). The lesions appeared when she was 18 years old, and grew darker with age. Such spots usually become apparent after sun exposure, but they do not usually vary in size. The subject did not take any medicine for a long time and did not receive any previous treatments for the lesions. Her mother, a 54-year-old female, had similar lesions on similar locations and similar ages of onset (Figure 2). The diagnosis of FNFZ was made and the two patients were treated with QSAL with a spot size of 3 mm, pulse duration of 100 ms, and a fluence of 7-8 J/cm2. They were advised to avoid sun exposure and apply sun protection cream after treatment. Both of them were treated for 3 sessions at intervals of 2 or 4 months and achieved a complete clearance without hyperpigmentation and hypo-pigmentation (Figure 3). Two years later, the patient was without relapse.