Blue Rubber Bleb Nevus Syndrome Manifest as Chronic Anemia in a 17-Year-Old Boy

Case Report

Austin J Dermatolog. 2016; 3(4): 1058.

Blue Rubber Bleb Nevus Syndrome Manifest as Chronic Anemia in a 17-Year-Old Boy

Zhong M¹, Song Z²*, Chen W³, Yang X² and Hao F²

¹Department of Dermatology, Outpatient Department, People’s Hospital, China

²Department of Dermatology, Third Military Medical University, China

³Department of Dermatology and Allergy, Technische Universitaet Muenchen, Germany

*Corresponding author: Zhiqiang Song, Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

Received: August 16, 2016; Accepted: October 03, 2016; Published: October 05, 2016


Blue Rubber Bleb Nevus Syndrome (BRBNS) is a rare systemic disorder characterized by cutaneous and Gastrointestinal (GI) vascular malformations that sometimes lead to occult blood loss with iron-deficiency anaemia or severe gastrointestinal bleeding. Here we report a case of a 17-year-old patient with BRBNS manifest as chronic anemia in his early years and review the clinical features and treatment of this rare disorder.

Keywords: Blue rubber bleb nevus syndrome; Bean syndrome; Anemia; Endoscopy

Case Report

A 17-year-old boy was admitted to department of pediatrics with ten years history of dizzy, lassitude, inertia. His chief complaint was dizziness that had initially developed 10 years ago. The patient did not pay more attention to this because it did not affect his study and life. Occasionally he felt cardiopalmus, upper abdominal pain but without fever, hematemesis and melena. After the illness, the patient had slightly poor memory and appetite and decreased body weight. Five years ago, his parent found a few blue eruptions on his trunk. Although more lesions appear with time, they did not take the patient to see a dermatologist, because they are told these lesions were nevi and did not need further treatments.

Physical examination revealed the patient presented with multiple violaceous or blue cutaneous lesions with various diameter on the face, trunk and the palmar surface of both feet. The lesions were compressible; after compression they slowly refilled with blood (Figure 1).