Conditions and Diseases that Cause Vitamin B12 Deficiency: Form Metabolism to Diseases

Special Article – Vitamin B12

Austin J Nutri Food Sci. 2020; 8(1): 1136.

Conditions and Diseases that Cause Vitamin B12 Deficiency: Form Metabolism to Diseases

Andres E*, Zulfiqar AA and Villalba NL

Department of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universities de Strasbourg, and Faculty of Medicine, University de Strasbourg, France

*Corresponding author: Andres E, Department of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universities de Strasbourg, and Faculty of Medicine, University de Strasbourg, Strasbourg, France

Received: January 06, 2020; Accepted: March 02, 2020; Published: March 09, 2020

Introduction

Although vitamin B12 (cobalamin) was isolated almost 60 years ago, its metabolism remains incompletely defined. In practice, cobalamin metabolism is complex and requires many processes and steps, any one of which, if not present, may lead to vitamin B12 deficiency [1,2]. The Figure 1 describes through a synthetic view the different stages of vitamin B12 metabolism used in clinical practice and the corresponding etiologies of cobalamin deficiency [3,4].