Nutritional Influence on Epigenetics and Disease

Review Article

Ann Nutr Disord & Ther. 2014;1(3): 1014.

Nutritional Influence on Epigenetics and Disease

Lundstrom K*

Pan Therapeutics, Lutry, Switzerland

*Corresponding author: Lundstrom K, PanTherapeutics, Rue des Remparts 4, CH1095 Lutry, Switzerland

Received: October 08, 2014; Accepted: November 25, 2014; Published: November 28, 2014


Nutrition plays an important role in disease prevention and even in therapeutic interventions. Nutrigenomics has provided invaluable information of the relationship between food intake and gene expression. Nutrition has also been linked to epigenetic mechanisms, which can substantially affect disease development. In this context, aberrant DNA methylation, histone modifications and RNA interference have been associated with increased risk and progress of a wide variety of diseases such as cancer, metabolic, and cardiovascular diseases and neurological disorders. In this review, examples will be presented on how nutritional interventions affect epigenetic mechanisms influencing disease development. Furthermore, design of personalized nutrition and its relationship to epigenetics is discussed.

Keywords: Nutrigenomics; Epigenetics; Personalized medicine; Nutrition and disease; DNA methylation; Histone modifications; RNA interference; Micro- RNA


During the past decade the importance of nutrition for human health has received more and more attention at both population and individual levels. In this context, numerous studies suggest a significant contribution of diet to global occurrence of cancer [1] and other diseases. Moreover, the rapid development in bioinformatics and DNA sequencing has allowed closer analysis of the effect of dietary intake on individual gene expression, leading to the establishment of nutrigenomics [2,3]. Similarly, the term foodomics has been introduced for the comprehensive high-throughput approach to exploit the relation between food science and improved nutrition [4]. Most importantly, modified epigenetic mechanisms in disease development have also been strongly linked to nutritional factors and life-style changes [5].

In this review, an overview of the effect on food intake on disease risk, prevention and therapy will be presented. The current status of nutrigenomics research will also be summarized. Attention will be paid to the influence of nutrition on epigenetic mechanisms. Finally, personalized nutritional and epigenetic solutions will be highlighted.

Nutrition and disease

There are numerous examples of direct and indirect effects of dietary intake on health and disease prevention. For instance, it has been suggested that over two-thirds of cancer-related deaths could most likely be prevented by nutritional interventions and lifestyle changes [6]. In this context, nutrition plays a substantial role in risk reduction and treatment of diseases such as metabolic and cardiovascular diseases, neurological disorders and cancer (Table 1).

Citation: Lundstrom K. Nutritional Influence on Epigenetics and Disease. Ann Nutr Disord & Ther. 2014;1(3): 1014. ISSN:2381-8891