Incidence of Hyperprolactinemia Induced by Atypical Antipsychotics

Research Article

Austin J Psychiatry Behav Sci. 2016; 3(2): 1055.

Incidence of Hyperprolactinemia Induced by Atypical Antipsychotics

Amaladoss AS¹*, Balram C² and Wang A²

¹Department of Psychiatry, Fredericton Mental Health Centre, Canada

²Department of Health & Wellness, Fredericton Mental Health Centre, Canada

*Corresponding author: Amaladoss AS, Department of Psychiatry, Fredericton Mental Health Centre, Fredericton, New Brunswick, Canada

Received: June 29, 2016; Accepted: August 27, 2016; Published: September 07, 2016


Background: Evidence support that Atypical Antipsychotics (AAPS) are effective in various psychiatric conditions, yet, evidence t1-t hyperprolactinemia induced atypical antipsychotics alters their benefit and risk ratio.

Objective: Prospective study was undertaken in a community setting, to determine the incidence of Hyperprolactinemia with atypical antipsychotics treatment.

Method: Patients were started on atypical antipsychotic for both schizophrenic and non-schizophrenic conditions. Serum Prolactin/monitored periodically from the baseline for one year duration. Total of 121 enrolled in the study, only 119 completed THE l year follow up. MALE 69 FEMALES 50; Olanzapine= 50; Risperidone= 59; Quetiapine= 8; Clozapine= 1. One patient on Olanzapine was detected with Pituitary Adenoma, hence omitted.

Data analysis: Descriptive and inferential analyses were done, except for clozapine, to ascertain the incidence of hyperprolactinemia and the relationship to age, gender and disease.

Results: % Hyperprolactinemia: Risperidone 69.49%>Olanzapine 32%> quetiapine12.5%

Male: Risperidone 64.86%>Olanzapine 23.33%>Quetiapine 0%

Female: Risperidone 77.27% >Olanzapine 45%> quetiapine 20% differences all statistically significant at 0.01 level. Schizophrenia 27.12%>Attention Deficit Disorder 20.34%>Bipolar Disorder18.64 Male 31.25%>Female 7.4% in attention deficit disorder Male 31.25%>Female 22% in Schizophrenia.

Mean prolactin: Male: Risperidone (21.33)>Olanzapine (14.81) Female: Risperidone (50.63)>Olanzapine (25.46) Male: Risperidone (22.31)> Olanzapine (15.47) in 3 months. Female: Risperidone (46.36)>Olanzapine (24.13) Highest LEVEL IN 41- 60 age with Risperidone = 52.03uG/I In 61+ AGE with Risperidone = 40.33uG/I

OR Olanzapine vs. Risperidone= 0.21 Male OR = 0.16 Female OR = 0.24.

Conclusion: Hyperprolactinemia may have significant HEALTH consequences both emotionally and physically and it is prudent to CHECK prolactin level periodically.

Keywords: Hyperprolactinemia; Antipsychotics; Incidence


Hyperprolactinemia has been shown to have many physiological consequences some of them quite severe including sexual dysfunction osteoporosis breast cancer insulin resistance syndrome cardiovascular morbidity and severe emotional effects (hostility depression and anxiety) [1] (Figure 1).